Role of circulating serum YKL-40 level in assessment of severity in hypersensitivity pneumonitis patients
ashraf, H., Keshar, N., Sabry, I., sharaf, H., ashraf, A., soliman, Y. (2023). Role of circulating serum YKL-40 level in assessment of severity in hypersensitivity pneumonitis patients. EKB Journal Management System, 1(1), 8-17. doi: 10.21608/ijhegy.2023.196687.1006
hala ashraf; Nasser Keshar; Irene Sabry; heba sharaf; amr ashraf; youssef soliman. "Role of circulating serum YKL-40 level in assessment of severity in hypersensitivity pneumonitis patients". EKB Journal Management System, 1, 1, 2023, 8-17. doi: 10.21608/ijhegy.2023.196687.1006
ashraf, H., Keshar, N., Sabry, I., sharaf, H., ashraf, A., soliman, Y. (2023). 'Role of circulating serum YKL-40 level in assessment of severity in hypersensitivity pneumonitis patients', EKB Journal Management System, 1(1), pp. 8-17. doi: 10.21608/ijhegy.2023.196687.1006
ashraf, H., Keshar, N., Sabry, I., sharaf, H., ashraf, A., soliman, Y. Role of circulating serum YKL-40 level in assessment of severity in hypersensitivity pneumonitis patients. EKB Journal Management System, 2023; 1(1): 8-17. doi: 10.21608/ijhegy.2023.196687.1006

Role of circulating serum YKL-40 level in assessment of severity in hypersensitivity pneumonitis patients

International Journal of Health Sciences (Egypt)
Volume 1, Issue 1, April 2023, Page 8-17  XML PDF (466.18 K)
Document Type: Original Article
DOI: 10.21608/ijhegy.2023.196687.1006
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Authors
hala ashraf email 1; Nasser Keshar2; Irene Sabry3; heba sharaf4; amr ashraf3; youssef soliman3
1department of clinical and chemical pathology Cairo university kasr el ainy
2Chest diseases, Cairo University
3chest diseases Cairo university
4clinical and chemical pathology cairo university
Abstract
BACKGROUND: Hypersensitivity pneumonitis (HP) is a diffuse parenchymal lung disease characterized by immune-mediated inflammation of lung parenchyma triggered by exposure to a wide variety of inhaled antigens. YKL-40 plays a fundamental role in protecting against pathogens, antigen-induced and oxidant-induced injury responses, inflammation, and tissue repair and remodeling. This is achieved by regulating many biological processes.OBJECTIVE: The aim of this study was to evaluate the YKL-40 serum level as a possible biomarker for disease activity in hypersensitivity pneumonitis.




METHODS: The study included 25 patients who were diagnosed primarily as hypersensitivity pneumonitis in Chest Department, Faculty of Medicine, Cairo University from April 2021 to August 2021. Moreover, 25 healthy age- and sex-matched controls were enrolled.RESULTS: YKL-40 was significantly higher among HP group, in fibrotic more that non-fibrotic subtype. YKL-40 had a negative correlation with oxygen saturation (SaO2) on room air, minimum SO2 in 6MWT and distance in 6MWT in HP patients. In addition, YKL-40 has a positive correlation with dyspnea score in HP patients. The fibrotic subgroup, compared to non-fibrotic subgroup had significantly higher serum YKL-40 level. A cut-off value of 629.4 pg/ml for serum YKL-40 level can distinguish between the HP patients and normal individuals (sensitivity =96%, and specificity =96%). Moreover, a cut-off value of 1181.5 pg/ml for serum YKL-40 level can distinguish between the fibrotic and non-fibrotic HP sub-types (sensitivity =85.7%, and specificity =81.8%).CONCLUSION: YKL-40 is a useful prognostic marker for hypersensitivity pneumonitis and can help in discriminating between fibrotic and non-fibrotic subtypes.
Keywords
Hypersensitivity pneumonitis; YKL-40; Biomarker; Fibrosis; Assessment of severity
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