Efficacy of Vonoprazan-based triple therapy for cure of H. Pylori Infection among patients attending GIT outpatient clinic at Suez Canal University Hospital
Mahrous, N., Nasrelden, E., Hassan, M., Aboelmagd, M. (2023). Efficacy of Vonoprazan-based triple therapy for cure of H. Pylori Infection among patients attending GIT outpatient clinic at Suez Canal University Hospital. EKB Journal Management System, 4(2), 506-513. doi: 10.21608/mid.2023.191490.1459
Nageh Louis Mahrous; Eman Nasrelden; Mariam Hassan; Mohamed Aboelmagd. "Efficacy of Vonoprazan-based triple therapy for cure of H. Pylori Infection among patients attending GIT outpatient clinic at Suez Canal University Hospital". EKB Journal Management System, 4, 2, 2023, 506-513. doi: 10.21608/mid.2023.191490.1459
Mahrous, N., Nasrelden, E., Hassan, M., Aboelmagd, M. (2023). 'Efficacy of Vonoprazan-based triple therapy for cure of H. Pylori Infection among patients attending GIT outpatient clinic at Suez Canal University Hospital', EKB Journal Management System, 4(2), pp. 506-513. doi: 10.21608/mid.2023.191490.1459
Mahrous, N., Nasrelden, E., Hassan, M., Aboelmagd, M. Efficacy of Vonoprazan-based triple therapy for cure of H. Pylori Infection among patients attending GIT outpatient clinic at Suez Canal University Hospital. EKB Journal Management System, 2023; 4(2): 506-513. doi: 10.21608/mid.2023.191490.1459

Efficacy of Vonoprazan-based triple therapy for cure of H. Pylori Infection among patients attending GIT outpatient clinic at Suez Canal University Hospital

Microbes and Infectious Diseases
Article 20, Volume 4, Issue 2, May 2023, Page 506-513  XML PDF (616.5 K)
Document Type: Original Article
DOI: 10.21608/mid.2023.191490.1459
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Authors
Nageh Louis Mahrousorcid 1; Eman Nasrelden2; Mariam Hassan email 3; Mohamed Aboelmagdorcid 1
1Endemic and Infectious diseases department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
2Internal Medicine Department, Faculty of Medicine, Suez Canal University ,Ismailia, Egypt
3Gastroenterology and Hepatology department, Ahmed Maher Teaching Hospital
Abstract
Background: Treatment of Helicobacter pylori (H.pylori) became mandatory for prevention and cure of most upper gastrointestinal complaints. Despite the varieties in available therapeutic options, achieving a high eradication rate is very challenging. Currently, vonoprazan based protocols are being introduced, and they provide promising outcomes. We aimed at studying vonoprazan efficacy and safety for cure of H.pylori among Egyptian patients. Methods: In a prospective cohort study, we included 300 patients who tested positive for H. pylori to receive vonoprazan-based triple therapy for two weeks. Then, we assessed the cure rate, improvement of symptoms and side effects. Results: We found that vonoprazan-based triple therapy achieved a cure rate of 90%. There was a remarkable improvement in all presenting symptoms after complete cure with this regimen. Few adverse effects were observed, not exceeding 9.3% of patients. Most common side effects were nausea (4.3%), burping (2.6%) and bloating (1.3%). Conclusions: vonoprazan-based triple therapy is effective and safe for cure of Helicobacter.
Keywords
Vonoprazan; Helicobacter pylori; Triple therapy, Eradication, Cure
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