Obstructive Sleep Apnea and Alzheimer’s Disease: A Two-way Street.
Abuzied, E., sayed, M., Amin, A., abdelaal, S., Magdy, R., abdelmotelb, A., Gad, E., gad, D. (2023). Obstructive Sleep Apnea and Alzheimer’s Disease: A Two-way Street.. EKB Journal Management System, 27(1), 50-55. doi: 10.21608/smj.2023.183672.1360
Enas Khalifa Abuzied; manar hamza sayed; Ahmed Ezzat Amin; sara kasem abdelaal; Rofaida M. Magdy; ayman ahmed abdelmotelb; Ebtisam Mohammed Gad; doaa mohamed gad. "Obstructive Sleep Apnea and Alzheimer’s Disease: A Two-way Street.". EKB Journal Management System, 27, 1, 2023, 50-55. doi: 10.21608/smj.2023.183672.1360
Abuzied, E., sayed, M., Amin, A., abdelaal, S., Magdy, R., abdelmotelb, A., Gad, E., gad, D. (2023). 'Obstructive Sleep Apnea and Alzheimer’s Disease: A Two-way Street.', EKB Journal Management System, 27(1), pp. 50-55. doi: 10.21608/smj.2023.183672.1360
Abuzied, E., sayed, M., Amin, A., abdelaal, S., Magdy, R., abdelmotelb, A., Gad, E., gad, D. Obstructive Sleep Apnea and Alzheimer’s Disease: A Two-way Street.. EKB Journal Management System, 2023; 27(1): 50-55. doi: 10.21608/smj.2023.183672.1360

Obstructive Sleep Apnea and Alzheimer’s Disease: A Two-way Street.

Sohag Medical Journal
Volume 27, Issue 1, 2023, Page 50-55  XML PDF (842.68 K)
Document Type: Original Article
DOI: 10.21608/smj.2023.183672.1360
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Authors
Enas Khalifa Abuzied email 1; manar hamza sayed2; Ahmed Ezzat Amin3; sara kasem abdelaal4; Rofaida M. Magdy5; ayman ahmed abdelmotelb6; Ebtisam Mohammed Gad7; doaa mohamed gad8
1department of Chest diseases and Tuberculosis,Faculty of medicine,Sohag University Hospital,Sohag
2Department of Neuropsychiatry, Faculty of Medicine, Sohag University. faculty of medicine
3Department of Neuropsychiatry, Faculty of Medicine, Sohag University Sohag university hospital
4internal medicine department.faculty of medicine.sohag university hospital
5Metabolic and Genetic Unit, Department of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt
6cardiothoracic surgery department sohag faculty of medicine
7Department of Chest diseases and Tuberculosis, Faculty of Medicine, Sohag University University
8ent department .faculty of medicine,Sohag university
Abstract
Abstract

Background:- Obstructive sleep apnea syndrome (OSAS) and Alzheimer’s disease (AD) are really widespread chronic diseases with increasing impact on the elderly group in our society. Nowadays, many causes of obstructive sleep apnea are well identified, while Alzheimer’s disease related mechanism are still not recognized, challenging the arrival to an actual treatment. Cognitive impairment is a clinical recognized consequence of obstructive sleep apnea, which is a result of intermittent hypoxia, disruptions of sleep architecture, oxidative stress, hemodynamic and transthoracic pressure changes, all of these factors increase the Alzheimer’s disease risk in patients with obstructive sleep apnea. On the other hand, Alzheimer’s disease can aid the emergence of obstructive sleep apnea by revealing serotonin and acetylcholine deficit; which are vital neurotransmitters for upper airway patency.

Purpose of this review article: - it aims to focus on the pathophysiologic relationships between Alzheimer’s disease and obstructive sleep apnea and the role of early detection and treatment of obstructive sleep apnea on the evolution of Alzheimer’s disease.

Conclusion: - Obstructive sleep apnea and Alzheimer's disease are a Two-way Street; having a bidirectional effect on each other’s pathogenesis. Alzheimer's disease can aid the emergence of obstructive sleep apnea which itself facilitates neuronal apoptosis and neurodegeneration. It is a necessary for neurologist to screen obstructive sleep apnea in any Alzheimer’s disease patient and vice versa.
Keywords
Alzheimer’ s disease; Obstructive sleep apnea; Pathophysiology
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