Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones
Emam, A., Kothayer, H., Ibrahim, S., El-Sadek, M. (2022). Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones. EKB Journal Management System, 65(132), 1547-1551. doi: 10.21608/ejchem.2023.14892.1905
Aya M. Emam; Hend Kothayer; Samy M. Ibrahim; Mohamed El-Sadek. "Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones". EKB Journal Management System, 65, 132, 2022, 1547-1551. doi: 10.21608/ejchem.2023.14892.1905
Emam, A., Kothayer, H., Ibrahim, S., El-Sadek, M. (2022). 'Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones', EKB Journal Management System, 65(132), pp. 1547-1551. doi: 10.21608/ejchem.2023.14892.1905
Emam, A., Kothayer, H., Ibrahim, S., El-Sadek, M. Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones. EKB Journal Management System, 2022; 65(132): 1547-1551. doi: 10.21608/ejchem.2023.14892.1905

Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones

Egyptian Journal of Chemistry
Volume 65, Issue 132, December 2022, Page 1547-1551  XML PDF (511.63 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.14892.1905
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Authors
Aya M. Emam1; Hend Kothayer email 1; Samy M. Ibrahim2; Mohamed El-Sadek2
1Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Egypt
2Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Egypt.
Abstract
Antibacterial agents structurally based on quinazolin-4-one pharmacophore, have been designed and synthesized. Where the targeted compounds 5a, c and 6a-c were in vitro screened against three gram positive and three gram negative bacteria strains compared to ciprofloxacin as reference drug. Most of compounds had moderate antibacterial activity while compound 5c showed the most significant activity and could be considered as a new lead compound for antibacterial drug design.
Keywords
Quinazolinone; antibacterial
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