Chalcone Scaffold: A masterpiece for medicinal chemistry recent biological insights | ||||
| Journal of advanced Biomedical and Pharmaceutical Sciences | ||||
| Article 5, Volume 6, Issue 2, April 2023, Page 90-96 PDF (1.31 MB) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/jabps.2023.184496.1177 | ||||
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| Authors | ||||
Mohamed Abdelaziz   1; Hesham A. Abou-Zied2; Eman A Beshr3; Alaa M. Hayallah4
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| 1Faculty of Pharmacy, Minia University, Minia Egypt | ||||
| 2Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt. | ||||
| 3Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia-61519, Egypt | ||||
| 4Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University | ||||
| Abstract | ||||
| In medicinal chemistry, privileged structures are frequently used as an effective template for finding new drugs. Chalcone is a typical simple sugar that occurs in a wide variety of naturally occurring compounds. Chalcone derivatives are also prepared in large quantities due to their simple synthesis. These organic substances and synthetic ones have demonstrated a wide range of intriguing biological behaviors with therapeutic potential for treating several diseases. This review aims to draw attention to recent research that shows chalcone to be a preferred solvent in medicinal chemistry. The primary goals of this review are to provide comprehensive information on chalcone-based hybrids, discuss recent advancements in the chemistry of chalcones with their diverse bioactive implications for the eradication of disease, and develop novel hybrids with desirable therapeutic mechanisms. | ||||
| Keywords | ||||
| Chalcone; Biological activity; EGFR kinase | ||||
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