Evaluation of The Analgesic and Anti-Inflammatory Activity of The Aqueous Extract of Anvillea radiata from South West Algeria | ||||
Egyptian Academic Journal of Biological Sciences, B. Zoology | ||||
Volume 14, Issue 2, December 2022, Page 473-479 PDF (508.41 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/eajbsz.2022.290569 | ||||
View on SCiNiTO | ||||
Authors | ||||
Fyad khadidja1; Belboukhari nasser1; Aici djahida2; Abdelkader Ammam3; Belmamoun Ahmed Reda4; Ghouti dalila3; Boukabene Fouzia kheira5 | ||||
1Laboratory of Bioactive Molecules and Chiral Separation (LMBSC) University of Bechar, Bechar, Algeria. | ||||
2Department of Exact Sciences, Normal Higher School, Bechar- 08000, Algeria. | ||||
3Laboratory of Pharmacognosy, Bio toxicology, and Biological Valorization of Plants, Moulay Tahar University, BP 20000, Saida, Algeria. | ||||
4Laboratory of Process, materials and environmental engineering, Djillali Liabes University, BP 22000, Sidi-Bel-Abbes, Algeria. | ||||
5Laboratory of Animal Production Sciences and Techniques, Mostaghanem; Moulay Tahar University, BP 20000, Saida, Algeria. | ||||
Abstract | ||||
Anvillea radiata is used in traditional medicine for the treatment of chest colds, indigestion, and gastrointestinal disorders. Our plant has hypoglycaemic, antitumor, anti-inflammatory, and antibacterial activity and is used for the treatment of dysentery. We have investigated the analgesic and anti-inflammatory activity of the aqueous extract of Anvillea radiata. In analgesic activity, we have used mice of the strain NMRI Albinos, weighing between 26 and 38 g (in vivo study). Acetic acid was used to induce writhes in mice, and the evaluation of the analgesic activity shows that the aqueous extract at 150 mg/kg of our plant induces a decrease in the number of abdominal cramps caused by 1% acetic acid. The aqueous extract of our plant has an analgesic effect almost equal to that of Diclofenac; in fact, the latter causes a pain inhibition of 30.28 1.1% and that of Anvillea radiata of 28.71 2.1% for a concentration of 150 mg/ kg. Our results of this research indicated that Anvillea radiata inhibited inflammation, which could explain its use in traditional medicine. | ||||
Keywords | ||||
Anvillea radiata; analgesic activity; anti-inflammatory activity; aqueous extract | ||||
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