Choriocarcinoma Syndrome Is a Potentially Fatal but Curable Condition | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 177, Volume 90, Issue 2, January 2023, Page 3156-3158 PDF (500.48 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2023.290612 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
walaa gamal soliman   ; Amr Muhammed; Aya Mahmoud; Shaimaa Roshdi; Esraa Mohammed; Marwa Khamis; Fatma Ayman; Mahmoud Elbadry; Reem Gamal; Elsayed M Ali
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| medical oncology, faculty of medicine, Sohag university, Sohag, Egypt. | ||||
| Abstract | ||||
| Background: Choriocarcinoma syndrome is rare and challenging in practice. The condition is fatal if it is associated with uncontrolled bleeding. Objectives: The current study aimed to present our experience managing a case of choriocarcinoma syndrome, which complicated a gestational trophoblastic disease. Patients and methods: A case of 35-year-old female with a history of molar pregnancy that was missed and diagnosed with choriocarcinoma stage 4. The patient suffered from a life-threatening gastrointestinal (GIT) bleeding. Results: The patient was managed by intensive transfusion protocol and chemotherapy [EMA-EP protocol (etoposide, methotrexate, actinomycin D, etoposide, cisplatin) and intercaecal methotrexate]. Severe life threating bleeding stopped after 72 hours of active management and blood transfusion. Following six cycles of this protocol, BHCG level returned to normal level with marked improvement of metastatic lesions. Conclusion: Choriocarcinoma syndrome is a life-threatening condition that requires intensive management. Cure-rate index is high if the condition is appropriately managed. | ||||
| Keywords | ||||
| Choriocarcinoma syndrome; Gestational trophoblastic disease; ovarian choriocarcinoma; Case report; Sohag University | ||||
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