Ameliorative Role of Saussurea Lappa Root Extract "Costus" on Thyroid Tissue Under the Toxic Effect of Carbimazole Induced Hypothyroidism. | ||||
Zagazig Journal of Forensic Medicine | ||||
Article 10, Volume 21, Issue 1, January 2023, Page 172-189 PDF (1.61 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjfm.2023.188310.1139 | ||||
View on SCiNiTO | ||||
Authors | ||||
Ereny Fekry 1; Mona Awny 2; George Refaat 3; Horeya Arafat 1 | ||||
1Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. | ||||
2Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||||
3Internal Medicine and Cardiology Departments, Suez Canal Authority, Ismailia, Egypt | ||||
Abstract | ||||
Introduction: Carbimazole is an antithyroid medication that is used for the treatment of hyperthyroidism. Carbimazole decreases serum thyroxine, thyroid-stimulating hormone, and thyrotropin-binding inhibitory immunoglobulins. However, carbimazole therapy can induce hypothyroidism and toxic effects on the thyroid gland tissue itself. Saussurea lappa root “Costus” is a traditional treatment that has anti-inflammatory, antioxidant, and immunomodulatory properties. Materials and methods: Twenty-four adult male albino rats were equally randomized into four groups and received all treatments orally by intragastric tube: group I served as control. Group II received Costus roots aqueous extract (50mg/kg body weight /2 days). Group III received carbimazole (2mg/100 gm body weight/day). Group IV received carbimazole concomitant with Costus roots aqueous extract. After 4 weeks, the animals were decapitated. Hematoxylin and eosin stain, periodic acid-Schiff reaction, and anti-calcitonin immunostaining were all performed on the prepared sections. Results: The Carbimazole group showed follicles lined by squamous epithelium, vacuolated colloid, and fused follicles. Carbimazole caused markedly decreased PAS-positive reaction due to colloid vacuolations and increased cytoplasmic immunoreactivity of C cells. In group IV, Costus could restore almost all the histopathological changes and improved C cells and decreased their cytoplasmic immunoreactivity. Conclusion: Saussurea lappa root “Costus” has a protective effect against carbimazole-induced thyroid damage. | ||||
Keywords | ||||
Saussurea lappa; Costus; Carbimazole; hypothyroidism; thyroid; toxicity | ||||
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