Strategies to Improve solubility of Oral Drugs
El Tahan, M., Hammady, T., Elgawish, M., Gad, S. (2023). Strategies to Improve solubility of Oral Drugs. EKB Journal Management System, 7(3), 1-14. doi: 10.21608/rpbs.2022.169532.1182
Mohammed Nabil El Tahan; Taha Mohamed Hammady; Mohamed Saleh Elgawish; Shadeed Gad. "Strategies to Improve solubility of Oral Drugs". EKB Journal Management System, 7, 3, 2023, 1-14. doi: 10.21608/rpbs.2022.169532.1182
El Tahan, M., Hammady, T., Elgawish, M., Gad, S. (2023). 'Strategies to Improve solubility of Oral Drugs', EKB Journal Management System, 7(3), pp. 1-14. doi: 10.21608/rpbs.2022.169532.1182
El Tahan, M., Hammady, T., Elgawish, M., Gad, S. Strategies to Improve solubility of Oral Drugs. EKB Journal Management System, 2023; 7(3): 1-14. doi: 10.21608/rpbs.2022.169532.1182

Strategies to Improve solubility of Oral Drugs

Records of Pharmaceutical and Biomedical Sciences
Volume 7, Issue 3, January 2023, Page 1-14  XML PDF (859.6 K)
Document Type: Mini-reviews
DOI: 10.21608/rpbs.2022.169532.1182
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Authors
Mohammed Nabil El Tahanorcid 1; Taha Mohamed Hammady2; Mohamed Saleh Elgawishorcid 3; Shadeed Gad email orcid 4
1pharmaceutics department, faculty of pharmacy, Suez canal university, Ismailia, Egypt
2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University
3Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia (41522), Egypt
4Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt
Abstract
One of the most common routes for drug administration is the oral route. It has many advantages like patient compliance, non-invasiveness and drug administration convenience. Oral administration accounts for over 60% of all established small-molecule medication products on the market. Oral drug absorption may be governed by many factors such as mucosal permeability, drug solubility and stability in the gastrointestinal tract. The trials to overcome these factors depend on understanding the biochemical, physicochemical, biological and metabolic barriers which affect the overall bioavailability of a drug. Enhancement of oral drug absorption can be achieved by many drug delivery systems and pharmaceutical technologies such as lipid-based carriers, micelles, nanocarriers, salt formation, solid dispersion, and complexation techniques using cyclodextrins. The strategies to improve the oral drug delivery will be discussed in details especially cyclodextrin complexation which is considered one of the most common strategies having great role in enhancing the oral drug delivery.
Keywords
Oral drugs; solubility; complexation; cyclodextrins
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