Therapeutic potential of targeting wingless-integrated/β-catenin/(Wnt/β-catenin) signaling pathway in Alzheimer's disease | ||||
| Records of Pharmaceutical and Biomedical Sciences | ||||
| Volume 7, Issue 3, January 2023, Page 71-80 PDF (624.61 K) | ||||
| Document Type: Mini-reviews | ||||
| DOI: 10.21608/rpbs.2023.189840.1206 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Rowan Sakr  1; Hoda Elsayed Mohamed 2; Dina Abo-El-Matty 3; Nehal Wahba 4; Alaa Samir Wahba 5
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| 1Medical Administration, Zagazig University, Zagazig 44519, Egypt | ||||
| 2Biochemistry, Faculty of Pharmacy, Zagazig university | ||||
| 3Faculty of Pharmacy - Suez Canal University | ||||
| 4Lecturer of pharmacology, Faculty of pharmacy, Zagazig university | ||||
| 5Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt | ||||
| Abstract | ||||
| Wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway plays a crucial role in the regulation of various processes including embryogenesis, organ development, injury repair, homeostasis and tissue remodeling. Upregulation or downregulation of this pathway is greatly implicated in different diseases such as liver and kidney diseases, lung fibrosis, osteoporosis, heart failure, vascular calcification, cellular senescence, neurodegenerative diseases and cancers. In brain, Wnt/β-catenin signaling is crucial for neuronal survival and neurogenesis, regulation of synaptic plasticity and blood-brain barrier integrity and function. Critically, Wnt/β-catenin signaling is highly suppressed in Alzheimer’s disease (AD) brain. Moreover, loss of Wnt/β-catenin signaling is associated with amyloid-β production, hyperphosphorylation of tau protein in the brain and enhanced neuron susceptibility to Aβ-induced apoptosis, while its activation rescues Aβ-induced neuronal cell death and behavioral deficits. Moreover, it has been showed that Wnt/β-catenin signaling is crucial for synaptic plasticity that is associated with higher brain functions including memory and learning. Therefore, restoring Wnt/β-catenin signaling might be an interesting target for the rational design of novel therapeutic interventions in AD patients. | ||||
| Keywords | ||||
| Wnt/β-catenin signaling; Alzheimer’s disease; amyloid; tau | ||||
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