Polymeric Nanoparticles Based Transdermal Hydrogel of Terbutaline Sulphate: Formulation and Evaluation
Marzouk, M., Elbakry, A., Elhosary, R., Abd ElRahman, N. (2023). Polymeric Nanoparticles Based Transdermal Hydrogel of Terbutaline Sulphate: Formulation and Evaluation. EKB Journal Management System, 3(2), 20-29. doi: 10.21608/aijpms.2023.83556.1083
Maha Marzouk; Asmaa Mohamed Elbakry; Rania Elhosary; Nehal Kamal Abd ElRahman. "Polymeric Nanoparticles Based Transdermal Hydrogel of Terbutaline Sulphate: Formulation and Evaluation". EKB Journal Management System, 3, 2, 2023, 20-29. doi: 10.21608/aijpms.2023.83556.1083
Marzouk, M., Elbakry, A., Elhosary, R., Abd ElRahman, N. (2023). 'Polymeric Nanoparticles Based Transdermal Hydrogel of Terbutaline Sulphate: Formulation and Evaluation', EKB Journal Management System, 3(2), pp. 20-29. doi: 10.21608/aijpms.2023.83556.1083
Marzouk, M., Elbakry, A., Elhosary, R., Abd ElRahman, N. Polymeric Nanoparticles Based Transdermal Hydrogel of Terbutaline Sulphate: Formulation and Evaluation. EKB Journal Management System, 2023; 3(2): 20-29. doi: 10.21608/aijpms.2023.83556.1083

Polymeric Nanoparticles Based Transdermal Hydrogel of Terbutaline Sulphate: Formulation and Evaluation

Azhar International Journal of Pharmaceutical and Medical Sciences
Volume 3, Issue 2, June 2023, Page 20-29  XML PDF (1.1 MB)
Document Type: Original research articles
DOI: 10.21608/aijpms.2023.83556.1083
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Authors
Maha Marzouk1; Asmaa Mohamed Elbakryorcid 1; Rania Elhosary2; Nehal Kamal Abd ElRahman email 2
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al- Azhar University, Cairo, Egypt
2Department of Pharmaceutics, National Organization of Drug Control and Research (NODCAR) Former, Egyptian Drug Authority (now), Cairo, Egypt
Abstract
Asthma is classified as chronic disease causing inflammation of the airways. Terbutaline sulphate is a synthetic β2-adrenoceptor stimulant used mainly in respiratory medicine. It has short half-life 3.4 hours so the study was done to evaluate the possibility of application of terbutaline sulphate loaded polymeric nanoparticles as transdermal drug delivery systems to give a sustained release dosage form. The technique that was chosen for the preparation of different formulae was ionic gelation method using tripolyphosphate and chitosan polymers and these formulae were evaluated for their polydespersity index and particle size. The most suitable formula (F5) was evaluated by entrapment efficiency and zeta potential. The nanoparticle suspension was incorporated in hydroxypropyl methylcellulose gel base and evaluated for visual appearance, pH, rheological properties and in-vitro release. The hydrogel was then evaluated for ex-vivo skin permeation. The chosen formula showed particle size 160.1 nm, entrapment efficiency 70.1, polydespersity index 0.336 and zeta potential 20.1 mv. The hydrogel showed good homogeneity with slightly whitish colour with pH 6.4 and the gel exhibited Higuchi diffusion model. In vitro test showed sustained release profile within 24 hours and the ex vivo test showed high permeation rate within 3 hours.
Keywords
Terbutaline sulphate; ionotropic gelation; Hydroxypropyl methylcellulose; hydrogel; transdermal
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