Adropin is Involved in the Ameliorative Effect of Chronic Exercise in Non-alcoholic Fatty Liver Rat Model
Fathy, M., Zamzam, M., Gergis, N., Hendy, N., Abdelfattah, M., Alsemeh, A. (2023). Adropin is Involved in the Ameliorative Effect of Chronic Exercise in Non-alcoholic Fatty Liver Rat Model. EKB Journal Management System, 29(4), 1071-1085. doi: 10.21608/zumj.2023.197729.2760
Maha Abdelhamid Fathy; Mohammed Sayed Ahmed Zamzam; Nawal Khalil Gergis; Nehal Ebrahim Hendy; Marwa Tharwat Abdelfattah; Amira Ibrahim Alsemeh. "Adropin is Involved in the Ameliorative Effect of Chronic Exercise in Non-alcoholic Fatty Liver Rat Model". EKB Journal Management System, 29, 4, 2023, 1071-1085. doi: 10.21608/zumj.2023.197729.2760
Fathy, M., Zamzam, M., Gergis, N., Hendy, N., Abdelfattah, M., Alsemeh, A. (2023). 'Adropin is Involved in the Ameliorative Effect of Chronic Exercise in Non-alcoholic Fatty Liver Rat Model', EKB Journal Management System, 29(4), pp. 1071-1085. doi: 10.21608/zumj.2023.197729.2760
Fathy, M., Zamzam, M., Gergis, N., Hendy, N., Abdelfattah, M., Alsemeh, A. Adropin is Involved in the Ameliorative Effect of Chronic Exercise in Non-alcoholic Fatty Liver Rat Model. EKB Journal Management System, 2023; 29(4): 1071-1085. doi: 10.21608/zumj.2023.197729.2760

Adropin is Involved in the Ameliorative Effect of Chronic Exercise in Non-alcoholic Fatty Liver Rat Model

Zagazig University Medical Journal
Article 13, Volume 29, Issue 4, July and August 2023, Page 1071-1085  XML PDF (1.9 MB)
Document Type: Original Article
DOI: 10.21608/zumj.2023.197729.2760
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Authors
Maha Abdelhamid Fathy email orcid 1; Mohammed Sayed Ahmed Zamzam1; Nawal Khalil Gergis2; Nehal Ebrahim Hendy1; Marwa Tharwat Abdelfattahorcid 3; Amira Ibrahim Alsemehorcid 4
1Medical physiology department-Faculty of medicine-Zagazig university
2Medical physiology department faculty of medicine Zagazig university
3Human ANATOMY & Embryology Department- Faculty of medicine- Zagazig university
4Human Anatomy and Embryology department, faculty of medicine, Zagazig university
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is characterized by abnormal fat metabolism in the liver due to non-alcoholic causes. Adropin is a peptide hormone with essential roles in maintaining metabolic homeostasis. Methods: 42 male rats were divided into 2 groups, each groups was sub-divided into 3 subgroups, group Ia: control 4weeks, group Ib: high fat diet (HFD) 4 weeks, group Ic: HFD 4 weeks +exercise, group IIa: control 12 weeks, group IIb: HFD 12 weeks and group IIc: HFD12 weeks + exercise. Serum Adropin, glucose, HOMA-IR, insulin, lipid profile, ALT, AST, TNFα, IL6, hepatic ROS, MDA and SOD were measured. Histopathological examination, immunohistochemical study and Mallory’s trichrome staining of the liver were made. Results: significant increase in insulin resistance, lipid profile parameters, ALT, AST, TNFα, IL6, hepatic ROS, MDA and a decrease in SOD were found in HFD groups. Histopathological examination revealed steatosis in group Ib and steatohepatitis in group IIb. These changes were associated with decrease in serum adropin level. Exercise in group Ic and IIc improved these changes with significant increase in adropin level. Conclusion: HFD induced functional and structural deterioration in the liver leading to NAFLD with significant decrease in serum adropin level. Exercise induced significant increase in serum adropin which may have a role in remission of hepatic inflammation, steatosis and steatohepatitis.
Keywords
Adropin; Non-alcoholic steatohepatitis; HOMA-IR; Aerobic exercise
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