Effect of vaginal pH on the efficacy of vaginal misoprostol for induction of mid trimester abortion | ||||
| Journal of Recent Advances in Medicine | ||||
| Article 2, Volume 4, Issue 1, January 2023, Page 9-15 PDF (705.69 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jram.2023.138160.1165 | ||||
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| Authors | ||||
Mona MI. Abohusien  ; Hanan A. Mohamed; Reda T. Mohamed
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| Obstetrics and Gynecology Department, Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt. | ||||
| Abstract | ||||
| Background: Missed abortion occurs when the deceased result of conception remains in the uterus beyond 20 weeks of gestation. Misoprostol, a prostaglandin analogue, is often employed for medical purposes. Objective: The aim of this study is to investigate whether change in the acidity of the vagina affects the pharmacokinetics of the misoprostol and, therefore, its efficacy for mid-trimester abortion induction Methodology: The study is a prospective study conducted on a cohort of 81 pregnant women (gestational age 14-26 weeks and failed abortion) at the obstetric department of Al-Zahra university hospitals in the interval from August2021 till February 2022 they were followed up for 24 hours. Results: Induction abortion intervals were substantially longer in group with pH ≥ (5) than in group with pH < (5) (22.33± 2.29 hrs. vs. 11.80± 1.63 hrs. p < 0.001). Group pH ≥ (5) showed an increased prevalence of fever and intense abdominal pain compared to group < (5) (p < 0.001 & 0.007 respectively). Conclusion: Misoprostol used vaginally for inducing of mid-trimester abortion is more effective when vaginal acidity is increased as it was more effective in group pH < (5). | ||||
| Keywords | ||||
| Acetic acid; misoprostol; second trimestric pregnancy termination; vaginal pH | ||||
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