L-arginine supplementation reduces blood pressure and plasma lipid levels in an animal model of perimenopause induced by 4-Vinylcyclohexene diepoxide
Arikawe, A., Olusanya, A., Udenze, I., Akinnibosun, O., Adejare, A., Olumide, O., Olatunji-Bello, I., Anselmo-Franci, J. (2019). L-arginine supplementation reduces blood pressure and plasma lipid levels in an animal model of perimenopause induced by 4-Vinylcyclohexene diepoxide. EKB Journal Management System, 39(1), 118-128. doi: 10.21608/besps.2019.6288.1008
Adesina Paul Arikawe; Adedunni Wumi Olusanya; Ifeoma Christiana Udenze; Olutope Arinola Akinnibosun; Abdullahi Adejare; Odunayo Moyosore Olumide; Ibiyemi Ibilola Olatunji-Bello; Janete Aparecida Anselmo-Franci. "L-arginine supplementation reduces blood pressure and plasma lipid levels in an animal model of perimenopause induced by 4-Vinylcyclohexene diepoxide". EKB Journal Management System, 39, 1, 2019, 118-128. doi: 10.21608/besps.2019.6288.1008
Arikawe, A., Olusanya, A., Udenze, I., Akinnibosun, O., Adejare, A., Olumide, O., Olatunji-Bello, I., Anselmo-Franci, J. (2019). 'L-arginine supplementation reduces blood pressure and plasma lipid levels in an animal model of perimenopause induced by 4-Vinylcyclohexene diepoxide', EKB Journal Management System, 39(1), pp. 118-128. doi: 10.21608/besps.2019.6288.1008
Arikawe, A., Olusanya, A., Udenze, I., Akinnibosun, O., Adejare, A., Olumide, O., Olatunji-Bello, I., Anselmo-Franci, J. L-arginine supplementation reduces blood pressure and plasma lipid levels in an animal model of perimenopause induced by 4-Vinylcyclohexene diepoxide. EKB Journal Management System, 2019; 39(1): 118-128. doi: 10.21608/besps.2019.6288.1008

L-arginine supplementation reduces blood pressure and plasma lipid levels in an animal model of perimenopause induced by 4-Vinylcyclohexene diepoxide

Bulletin of Egyptian Society for Physiological Sciences
Article 9, Volume 39, Issue 1, June 2019, Page 118-128  XML PDF (477.67 K)
Document Type: Original Article
DOI: 10.21608/besps.2019.6288.1008
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Authors
Adesina Paul Arikawe email orcid 1; Adedunni Wumi Olusanya2; Ifeoma Christiana Udenze3; Olutope Arinola Akinnibosun4; Abdullahi Adejare4; Odunayo Moyosore Olumide5; Ibiyemi Ibilola Olatunji-Bello5; Janete Aparecida Anselmo-Franci6
1Physiology/Basic Medical Sciences/University of Lagos/Lagos/Nigeria
2Pharmacology, Therapeutics & Toxicology/Faculty of Basic Medical Sciences/ University Of Lagos/Lagos/Nigeria
3Clinical Pathology/ Faculty of Clinical Sciences/University of Lagos/Lagos/Nigeria
4Physiology/Faculty of Basic Medical Sciences/University of Lagos/Lagos/Nigeria
5Physiology/Faculty of Basic Medical Sciences/ Lagos State University/Lagos/Nigeria
6Morphology, Physiology and Basic Pathology/Faculdade de Odontologia/University of São Paulo/Ribeirao Preto/Brazil
Abstract
The incidence of women developing high blood pressure during perimenopause has been documented and is sustained till menopause. However, no study till date on beneficial effects of L-arginine supplementation on BP during perimenopause in humans and animal models of perimenopause.

Female rats 28 days old were divided into 3 groups; Control group was injected (SC) daily with Corn oil (2.5 μl/g BW) for 15 days, allowed to grow till 12th week; VCD group was injected (SC) daily with 4-vinylcyclohexene diepoxide (160 mg/kg BW) diluted in Corn oil (2.5 μl/g BW) for 15 days, allowed to grow till 12th week; VCD + L-ARG group was injected as VCD group, allowed to grow till 8th week, then administered oral 100mg/kg L-arginine daily for additional 4 weeks. Caudal BP was measured with tail-cuff apparatus (Kent Scientific CODA system) at weeks eight, ten, and twelve. Terminal BP was also measured with a power-lab apparatus and blood samples were subsequently collected for measurement of plasma lipid profile.

L-arginine supplementation significantly reduced systolic, diastolic and mean arterial BP parameters in the VCD + L-ARG group compared to the Control and VCD groups (P < 0.05). It also significantly reduced total cholesterol and LDL concentrations in the VCD + L-ARG group compared to the Control and VCD groups (P < 0.05). HDL concentration was significantly higher in the VCD and VCD + L-ARG groups compared to the Control group (P < 0.05). These results show that L-arginine supplementation ameliorates some cardiovascular risk factors during perimenopausal transitory period.
Keywords
perimenopause; L-arginine; blood pressure; Lipid profile
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