Relation between Serum Uric Acid and Peripheral Neuropathy in Cases of Type 2 Diabetes Mellitus | ||||
| International Journal of Medical Arts | ||||
| Article 1, Volume 5, Issue 1, January 2023, Page 2932-2937 PDF (855.23 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2023.175933.1558 | ||||
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| Authors | ||||
Hossam Abdelmonem Ali1; Ahmed Salama Al-Adl   2
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| 1Department of Neurology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt | ||||
| 2Department of Internal Medicine, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt | ||||
| Abstract | ||||
| Background: Peripheral neuropathy is a common sequel of diabetes mellitus type 2, and may occur as an initial manifestation of diabetes. The role of uric acid in diabetic neuropathy as a microvascular complication of diabetes type 2 has been reported in numerous studies. Aim of the Work: The objective of the study is to assess the relationship between serum uric acid levels and diabetic neuropathy in cases with diabetes mellitus type 2. Patients and Methods: A case-controlled study included 168 cases with type 2 diabetes mellitus, conducted at internal medicine and neurology departments. Two groups of diabetic patients [type 2 DM] each one was 84 in number; 1st one diabetic with peripheral neuropathy and 2nd group was diabetics without peripheral neuropathy. All patients submitted to history taking, general and neurological examination, biochemical study, and electro-physiological examination. Results: The serum uric acid mean level was a statistically significant higher in the 1st group in comparison with the 2nd group [4.71 ± 0.97 vs. 4.35 ± 0.9]. The severity of polyneuropathy in the 1st group showed that 38 patients had mild diabetic peripheral neuropathy [DPN], while 22 patients had moderate DPN and 24 patients had severe DPN. Uric acid levels in these three subgroups were respectively as follows: [4.6 ± 0.8] mg/dl, [4.9 ± 0.5] mg/dl and [5.3 ± 0.6] mg/dl. Regarding the relation of severity of peripheral polyneuropathy to serum uric acid level, there was a statistically significant relation between mild and moderate poly-neuropathy and a statistically significant relation between Mild to severe polyneuropathy. The logistic regression model revealed that an increase in uric acid level is an important indicator for a more severe degree of peripheral neuropathy. Conclusion: The severity of diabetic polyneuropathy is increased with the increase of uric acid serum level. | ||||
| Keywords | ||||
| Diabetic peripheral neuropathy; Electrophysiological study; Serum uric acid | ||||
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