Protective and ameliorative effects of Curcumin and/or Quercetin against gentamicin induced testicular damage in rats

Samy, Maha; Ahmed, Reda S. I.; Shanab, Obeid; Maher, Zainab M.; Sedik, Wael F.; Mostafa, Laila; El-ghoneimy, Ashraf A.

doi:10.21608/svu.2023.173096.1236

	Protective and ameliorative effects of Curcumin and/or Quercetin against gentamicin induced testicular damage in rats
SVU-International Journal of Veterinary Sciences
Volume 6, Issue 1 - Serial Number 15, March 2023, Page 63-73 PDF (307.82 K)
Document Type: Research article
DOI: 10.21608/svu.2023.173096.1236
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Authors
Maha Samy¹; Reda S. I. Ahmed¹; Obeid Shanab ²; Zainab M. Maher^* ³; Wael F. Sedik^* ⁴; Laila Mostafa^* ²; Ashraf A. El-ghoneimy ¹
¹Pharmacology Department, Faculty of Veterinary Medicine, South Valley University, Egypt
²Biochemistry Department, Faculty of Veterinary Medicine, South Valley University, Egypt,
³Pathology and Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Egypt
⁴Department of Medical Biochemistry, Faculty of Medicine, Minia University, Egypt.
Abstract
The aminoglycoside Gentamicin is a commonly used antibiotic counteracting the Gram-ve microorganisms. Rats administered with Gentamicin showing a reduced testicular weight and inhibited spermatogenesis, as gentamicin generates ROS, decreasing the antioxidant reserve and accelerate mitochondrial dysfunction which then leads to apoptosis and testicular tissue destruction. This study was designed to investigate the protective effects of curcumin and/or quercetin on the gentamicin induced testicular damage or toxicity in sexually mature adult rats. Pre-treatment with curcumin and/or quercetin, markedly inhibited and ameliorated the reduction in sperm count, viability, motility and sperm production in gentamicin treated rats. Moreover curcumin and/or quercetin, significantly reduce teratospermia including head or tail abnormalities that observed in the gentamicin treated rats. These abnormalities were effectively normalized by curcumin and/or quercetin pretreatment improving the testicular tissue via counteracting of ROS, improvement of spermatogenesis and ameliorate the sperms quality and quantity. In conclusion supplementation of curcumin and/or quercetin improving the sperm count and morphology via testicular cell repair, counteracting the undesirable effect of gentamicin. Key words: Gentamicin, Curcumin, Quercetin, ROS, Sperm.
Keywords
Key words: Gentamicin; Curcumin; Quercetin; ROS; Sperm


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