Evaluation Of Neopterin Level And Disease Severity In Patients With Psoriasis Vulgaris Treated With Narrowband UVB | ||||
| SVU-International Journal of Medical Sciences | ||||
| Article 8, Volume 6, Issue 2, July 2023, Page 81-87 PDF (310.71 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/svuijm.2023.183238.1480 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Eisa Mohamed Hegazy1; Hassan Mohamed Ibrahim1; Fatma Elsayed Abd Elfatah  1; Ali Mohamed Younis2
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| 1Dermatology, Venereology, and Andrology Department, Faculty of Medicine, South Valley University, Qena, Egypt | ||||
| 2Dermatology, Venerology, and Andrology Department, Faculty of Medicine, Aswan University, Aswan, Egypt | ||||
| Abstract | ||||
| Background: Psoriasis is an immunity chronic hyperproliferative illness. An indicator of cellular immunity is neopterin, a biological substance. According to reports, psoriasis causes an increase in serum neopterin levels, which thereafter drop as a result of treatment. Objectives: To evaluate serum levels of neopterin in patients with psoriasis vulgaris. Patients and methods: This study is a case-control study that involved 30 patients with psoriasis and 30 healthy subjects as control. Patients were treated with Narrowband UVB (3session /week ) for 3 months. Serum neopetrin levels were measured pre and post treatment by performing an enzyme-linked immune sorbent assay (ELISA). All patients were clinically and photographically evaluated using Psoriasis Area and Severity Index (PASI score). Results: A Statistically significant differences in serum Neopterin level have been found in psoriatic patients comparing to healthy controls. The mean of serum Neopterin levels were 2.8 and 0.7 (nmol/L) in psoriatic patients and healthy controls, respectively (P< 0.001). We found Statistically significant improvement in disease severity, and a significant decrease in PASI scores was detected. The median of PASI score pre and post NB-UVB therapy was 31.4 and 8, respectively, with statistical significant difference (P<0.001). We noted significant difference between serum levels of Neopterin in patients before and after treatment, with a higher level of serum Neopterin among patients before treatment (P< 0.001). Conclusion: Serum neopterin was highly significant in the psoriatic patients compared to healthy controls (p < 0.05). A significant decrease was observed in serum neopterin level after the narrowband UVB therapy. | ||||
| Keywords | ||||
| Serum neopterin; Psoriasis; PASI | ||||
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