Pharmacological Studies on Bleomycin as Cancer Therapy and Protective Effect of Aged Garlic | ||||
| Zagazig Veterinary Journal | ||||
| Article 27, Volume 45, Supplementary 1, October 2017, Page 267-276 PDF (145.63 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zvjz.2017.29247 | ||||
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| Authors | ||||
| Sabry M.A. Abdel-Motal1; Mohamed H. Khairy1; Ahmed A. S. Mohamed1; Magdy F. Abou El-Fotoh2; Shimaa A. Abdel –Aziz1 | ||||
| 1Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt | ||||
| 2Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| The pharmacological impacts of bleomycin as anticarcinogenic agents and the protective effect of aged garlic were done in current study. Eighty mature male albino mice were divided into 8 groups (each ten mice), group one was kept as a negative control, group two which was injected intraperoteneally with bleomycin. Group 3, which was given orally aged garlic, group 4 was inoculated with Ehrlich Ascites Carcinoma cells (EAC) , animals of group 5were administrated aged garlic and injected with EAC cells while group 6 was given simultaneously EAC cells and bleomycin I/P , group 7 was injected bleomycin I/P and administrated garlic 8 days later and group 8 took both bleomycin and garlic before inoculation of EAC cells by 8 days. Our results revealed that there were side effects of bleomycin on GSH, ROS, CAT, GPX and GR in the inoculated groups with EAC cells and confirmed by biochemical analysis. Aged garlic suppresses the progression of EAC cells and prevents their developmental effects | ||||
| Keywords | ||||
| Bleomycin; cancer therapy; Protective Effect; Aged Garlic | ||||
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