EFFECT OF MONOSODIUM GLUTAMATE AND VITAMIN C ON RAT PAROTID GLAND | ||||
| Alexandria Dental Journal | ||||
| Article 11, Volume 48, Issue 1, April 2023, Page 80-85 PDF (1.08 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/adjalexu.2022.126896.1261 | ||||
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| Authors | ||||
Sara Mohamed Abdel Rahman  1; Salwa Abdelsamad Younis2; Afaf Abdelkhalek El Sawa3; Nesma Mohamed Khalil2
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| 1Department of Oral Biology, Faculty of Dentistry, Alexandria University, Egypt | ||||
| 2Department of Oral Biology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt | ||||
| 3Professor, Department of Oral Biology, Faculty of Dentistry, Alexandria University, Egypt | ||||
| Abstract | ||||
| Background: Monosodium glutamate (MSG) is one of the most frequently used taste enhancers in modern food industry. Long term consumption of high doses of MSG can elevate the oxidative stress mainly by generation of reactive oxygen species and lead to cytotoxicity in multiple tissues in the body. Vitamin C is a well-known potent antioxidant and has been shown to protect various tissues against oxidative stress induced damage. Aim of the study: To determine the histological effect of monosodium glutamate and vitamin C on parotid salivary glands of albino rats. Materials and methods: 30 male adult albino rats were equally divided into 3 groups; control group that received 1 ml distilled water orally once daily, MSG group that received 30 mg/kg body weight of Monosodium Glutamate daily and MSG+ Vit C group that received a daily dose of 30 mg/kg bodyweight of MSG followed by 100mg/kg bodyweight of Vitamin C in distilled water by oral gavage. After 8 weeks, rats were euthanized, parotid glands were dissected out to be processed for histological examination. Results: Histological examination of parotid of MSG group revealed acinar cells with signs of atrophy and degeneration demonstrated as cytoplasmic vacuolations, pyknotic or apoptotic nuclei. Secretory striated duct showed luminal dilatation and partial loss of basal striations. MSG+ Vit C group showed more preservation of normal architecture of serous acini and ducts. Conclusion: MSG produced significant degenerative effects on parotid glands of albino rats and co-administration of vitamin C was effective in protecting gland tissue against MSG-induced damage. | ||||
| Keywords | ||||
| Monosodium glutamate; Vitamin C; Parotid glands; Albino rats; Antioxidant | ||||
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