Persistent changes in the brain of Immature Rats Experiencing febrile seizures | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 66, Issue 12, December 2023, Page 347-351 PDF (219 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2023.189698.7516 | ||||
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| Authors | ||||
Omnia Ashoor Ali   1; Haitham Sharf Eldein Mohamed 2; Nasr Mohamed Radwan3; REEM H ELGEBALY4
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| 1Biophysics department. Faculty of Science, Cairo University, Egypt | ||||
| 2Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt | ||||
| 3Zoology Department, Faculty of Science, Cairo University, Giza, Egypt | ||||
| 4Biophysics Department Faculty of Science – Cairo University Giza - Egypt | ||||
| Abstract | ||||
| The most prevalent neurological condition in children is febrile seizures (FS), which affects humans. It is possible to explore the underlying processes of FS that are connected to the onset of epilepsy and associated comorbidities using models of hyperthermia for seizure induction. The current study concentrates on examining the changes in the expression of a gap junction protein in two brain areas; the hippocampus and the cortex in young rats who experienced FS. Animals used in experiments were split into two groups, the cage control group, and the hyperthermia-stimulated FS group. Each group of the two groups was further subdivided into young (Y) and Adult (A) groups. Reduction in the expression of Cx43 has been detected in both groups of animals (Y & A) and was suggested to be related to seizure activity. The present study sheds more light on the possible role played by gap junction proteins in FS and epilepsy. | ||||
| Keywords | ||||
| Febrile seizure; Hyperthermia; Connexin; Gap junction protein | ||||
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