Evaluation of Chemokine CCL18 Level in Cord and Peripheral Blood as a Predictor of Intraventricular Hemorrhage in Preterm Infants
Abd El Razek, S., ElRaggal, N., Ismail, R., Yousry, S., Amer, H., Abdel Dawoud, M. (2023). Evaluation of Chemokine CCL18 Level in Cord and Peripheral Blood as a Predictor of Intraventricular Hemorrhage in Preterm Infants. EKB Journal Management System, 91(1), 3825-3831. doi: 10.21608/ejhm.2023.293462
Suzan Abd El Razek Mohamed Abd El Razek; Nehal M ElRaggal; Rania I H Ismail; Shaimaa A Yousry; Hanaa A H Amer; Mohamed O. Abdel Dawoud. "Evaluation of Chemokine CCL18 Level in Cord and Peripheral Blood as a Predictor of Intraventricular Hemorrhage in Preterm Infants". EKB Journal Management System, 91, 1, 2023, 3825-3831. doi: 10.21608/ejhm.2023.293462
Abd El Razek, S., ElRaggal, N., Ismail, R., Yousry, S., Amer, H., Abdel Dawoud, M. (2023). 'Evaluation of Chemokine CCL18 Level in Cord and Peripheral Blood as a Predictor of Intraventricular Hemorrhage in Preterm Infants', EKB Journal Management System, 91(1), pp. 3825-3831. doi: 10.21608/ejhm.2023.293462
Abd El Razek, S., ElRaggal, N., Ismail, R., Yousry, S., Amer, H., Abdel Dawoud, M. Evaluation of Chemokine CCL18 Level in Cord and Peripheral Blood as a Predictor of Intraventricular Hemorrhage in Preterm Infants. EKB Journal Management System, 2023; 91(1): 3825-3831. doi: 10.21608/ejhm.2023.293462

Evaluation of Chemokine CCL18 Level in Cord and Peripheral Blood as a Predictor of Intraventricular Hemorrhage in Preterm Infants

The Egyptian Journal of Hospital Medicine
Article 10, Volume 91, Issue 1, April 2023, Page 3825-3831  XML PDF (440.42 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2023.293462
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Authors
Suzan Abd El Razek Mohamed Abd El Razek; Nehal M ElRaggal; Rania I H Ismail; Shaimaa A Yousry; Hanaa A H Amer; Mohamed O. Abdel Dawoud
Abstract
Background: Intraventricular hemorrhage (IVH) is a serious complication of prematurity. While early diagnosis is crucial for appropriate management, determining high-risk neonates might prompt extra preventive measures. Low levels of Chemokine (C-C motif) ligand 18 (CCL18) may predict the development of IVH in preterms.
Aim of the study: to evaluate the association between CCL18 level in cord and peripheral blood and the incidence of IVH in preterm neonates. Patients and methods:This prospective cohort study included, 51 preterm neonates aged (29-32 weeks). Neonates with perinatal hypoxia, brain malformations, or major congenital malformations were excluded. CCL18 was analyzed in cord blood at birth and in the peripheral blood on day 2 of life. Cranial ultrasound scans were done on day 3 and day 7.
Results: Out of the studied neonates, only 44 were enrolled,18 males (40.9%) and 26 females (59.1%). The incidence of IVH was 52.3% (23/44). No statistical differences were observed in gestational age (p=0.59), weight (p=0.192), gender (p=0.139), maternal illness (p=0.355), and Apgar score (p=0.961) in both groups. Cord and blood CCL18 were comparable in patients with and without IVH (p=0.518 & p=0.70 respectively). Impaired neurological examination and low platelet count were significantly associated with IVH (p < 0.05).
Conclusion: The current work suggests that the CCL18 level in the cord or peripheral blood can’t indicate preterm neonates at a higher risk of developing IVH. Through neurological examination, sequential cranial ultrasounds and platelet counts might be a more convenient tool for early detection of IVH in preterm babies.
 
Keywords
CCL18; Intraventricular hemorrhage; prematurity; Neonatal; Neurodevelopment
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