Computational analysis of data on the functional and structural effects of single nucleotide polymorphisms (SNPs) on inbred ovenbirds
I., M., O., Y., A., Y. (2023). Computational analysis of data on the functional and structural effects of single nucleotide polymorphisms (SNPs) on inbred ovenbirds. EKB Journal Management System, 18(1), 1-4. doi: 10.21608/ejsgs.2023.293600
Musa S. I.; Yahaya K. O.; Yahaya A.. "Computational analysis of data on the functional and structural effects of single nucleotide polymorphisms (SNPs) on inbred ovenbirds". EKB Journal Management System, 18, 1, 2023, 1-4. doi: 10.21608/ejsgs.2023.293600
I., M., O., Y., A., Y. (2023). 'Computational analysis of data on the functional and structural effects of single nucleotide polymorphisms (SNPs) on inbred ovenbirds', EKB Journal Management System, 18(1), pp. 1-4. doi: 10.21608/ejsgs.2023.293600
I., M., O., Y., A., Y. Computational analysis of data on the functional and structural effects of single nucleotide polymorphisms (SNPs) on inbred ovenbirds. EKB Journal Management System, 2023; 18(1): 1-4. doi: 10.21608/ejsgs.2023.293600

Computational analysis of data on the functional and structural effects of single nucleotide polymorphisms (SNPs) on inbred ovenbirds

Egyptian Journal of Sheep and Goats Sciences
Volume 18, Issue 1, April 2023, Page 1-4  XML PDF (445.21 K)
Document Type: Original Article
DOI: 10.21608/ejsgs.2023.293600
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Authors
Musa S. I.1; Yahaya K. O.1; Yahaya A.2
1Department of Animal Science, Nasarawa State University, Keffi, Shabu- Lafia Campus, Nigeria
2Department of Animal Science and Technology, Federal University of Technology, Owerri, Nigeria
Abstract
The objective of this study was to evaluate the functional and structural effects of single nucleotide polymorphism (SNP) on ovine interferon tau using computational methods. Data on ovine interferon was retrieved from data base of National Center for Biotechnology Information ( Gen Bank). Functional effects of substitution of Leucin by Proline at position 26 of interferon protein chain was predicted using Protein Variation Effect Analyzer, Panther server and Poly phen 2 (Polymorphism phenotyping) respectively. Provean score of - 5.828 was obtained, indicating a deleterious effect of the amino acid substitution. Panther server indicated damaging effect of the SNP with Pdel (probability of deleterious effect) of 0.5. Similarly, Poly phen 2 showed damaging effect of the amino acid substitution. Mudpred 2 server indicated loss of sulfation to be the mechanism of structural change. It can be concluded that substitution of Leucin by proline at position 26 of the protein sequence interferon tau resulted in deleterious effect on the functionality of ovine interferon tau. Studies in single nucleotide polymorphism on ovine interferon tau can provide better understanding of biomarkers associated with efficiency of maternal pregnancy recognition in the ovine species.
Keywords
Ovine; Interferon; SNP; Prediction
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