From Synthesis to Biological Impact of Ru (II) Complexes: Preparation, Characterization, Antimicrobial, Antioxidant scavenging and Enzymatic inhibitory activities
Amri, N., Mukhrish, Y., Gatri, R., Gürbüz, N., Özdemir, I., Dridi, K., Hamdi, N. (2023). From Synthesis to Biological Impact of Ru (II) Complexes: Preparation, Characterization, Antimicrobial, Antioxidant scavenging and Enzymatic inhibitory activities. EKB Journal Management System, 66(5), 203-214. doi: 10.21608/ejchem.2023.122780.5495
Nasser Amri; Yousef E. Mukhrish; Rafik Gatri; Nevin Gürbüz; Ismail Özdemir; Khaireddine Dridi; Naceur Hamdi. "From Synthesis to Biological Impact of Ru (II) Complexes: Preparation, Characterization, Antimicrobial, Antioxidant scavenging and Enzymatic inhibitory activities". EKB Journal Management System, 66, 5, 2023, 203-214. doi: 10.21608/ejchem.2023.122780.5495
Amri, N., Mukhrish, Y., Gatri, R., Gürbüz, N., Özdemir, I., Dridi, K., Hamdi, N. (2023). 'From Synthesis to Biological Impact of Ru (II) Complexes: Preparation, Characterization, Antimicrobial, Antioxidant scavenging and Enzymatic inhibitory activities', EKB Journal Management System, 66(5), pp. 203-214. doi: 10.21608/ejchem.2023.122780.5495
Amri, N., Mukhrish, Y., Gatri, R., Gürbüz, N., Özdemir, I., Dridi, K., Hamdi, N. From Synthesis to Biological Impact of Ru (II) Complexes: Preparation, Characterization, Antimicrobial, Antioxidant scavenging and Enzymatic inhibitory activities. EKB Journal Management System, 2023; 66(5): 203-214. doi: 10.21608/ejchem.2023.122780.5495

From Synthesis to Biological Impact of Ru (II) Complexes: Preparation, Characterization, Antimicrobial, Antioxidant scavenging and Enzymatic inhibitory activities

Egyptian Journal of Chemistry
Volume 66, Issue 5, May 2023, Page 203-214  XML PDF (1.06 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.122780.5495
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Authors
Nasser Amri1; Yousef E. Mukhrish1; Rafik Gatri2; Nevin Gürbüz3, 4; Ismail Özdemir3, 4; Khaireddine Dridi5; Naceur Hamdi email 5
1Department of Chemistry, Faculty of Science, Jazan University, P.O. Box 2097, Jazan 45142; Saudi Arabia
2Laboratoire de Synthèse Organique Sélective et Hétérocyclique Évaluation Biologique LR17ES01 Faculté des Sciences de Tunis Faculté des Sciences de Tunis Campus Universitaire 1092 Tunis, Tunisie, Université de Tunis El Manar
3İnönü University, Catalysis Research and Application Center, 44280-Malatya, Turkey
4İnönü University, Faculty of Science and Art, Department of Chemistry, 44280 Malatya, Turkey
5Department of Chemistry, College of Science and Arts at Ar Rass, Qassim University, Ar Rass, 51452, Saudi Arabia
Abstract
The reaction of [RuCl2(p-cymene)]2 with in situ prepared Ag-N-heterocyclic carbene (NHC) complexes yields a series of [RuCl2(p-cymene) (NHC)] complexes 3. The structures of complexes were established by appropriate spectroscopic methods and elemental analyses. The biological activities of the synthesized ligands and their Ru (II) complexes as acetylcholinesterase, antimicrobial, and antioxidant agents were evaluated. The lowest MICs values were obtained with the two complexes 3b and 3d. The enzymatic inhibitory investigation against acetylcholinesterase (AChE) and tyrosinase (TyrE), showed that the two complexes 3b and 3d are the most potent inhibitors against (AchE) with an IC50 of 2.52 and 5.06 µg mL-1 respectively, and against (TyrE) with an IC50 of 19.88 and 24.95 µg mL-1 respectively. Additionally, DPPH (2,2-diphenyl-1-picrylhydrazyl) has been tested for its ability to scavenge hydrogen peroxide and free radicals. According to our results, these compounds exhibit excellent radical scavenging properties
Keywords
: Biological activity; N-Heterocyclic carbene; benzimidazolium salts; ruthenium complexes; silver complexes
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