The Possible Protective Role of Tannic Acid against Monosodium Glutamate-Induced Pancreatic and Liver Toxicity in Adult Male Albino Rats: Biochemical, Histological and Immunohistochemical Study | ||||
| Journal of Medical Histology | ||||
| Article 6, Volume 5, Issue 2, December 2021, Page 171-187 PDF (1.92 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jmh.2023.174826.1108 | ||||
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| Authors | ||||
| Sherine Mohammed* 1; Palkis Mohamed2; Soheir Mohamed2; Rania Radwan2 | ||||
| 1Departments of Histology, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||||
| 2Departments of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||||
| Abstract | ||||
| Background: Monosodium Glutamate (MSG) is a common flavor enhancer that has several toxic effects on different body organs. Tannic acid (TA) is a naturally occurring antioxidant component with several pharmacological properties. Objectives: The present study was conducted to assess the possible protective role of TA on MSG-induced hepatic and pancreatic toxicity. Materials and Methods: 40 adult male albino rats were divided into 4 equal groups. Group I was the control group, group II received TA, group III received MSG, and group IV received TA + MSG for 4 weeks. TA and MSG were received in a dose of 100mg/kg BW and 2g/kg BW respectively. At the end of the study, the evaluation was done by biochemical analysis and histopathology. Immunohistochemistry was used to measure BAX antibody and insulin expression. Results: MSG increased the levels of pancreatic enzymes; amylase and lipase enzymes, as well as blood sugar levels. Liver enzymes were also increased. Histologically, degenerative changes were observed in the liver and pancreas with increased islets surface area. MSG increased the expression of the apoptotic marker BAX and decreased β-cells percentage. Co-administration of TA with MSG attenuated these degenerative effects. Conclusion: MSG has toxic effects on the liver and pancreas leading to increased blood glucose levels. TA has an antioxidant role against MSG toxicity with a reduction of blood glucose levels. | ||||
| Keywords | ||||
| Insulin; liver toxicity; monosodium glutamate; pancreatic toxicity; tannic acid | ||||
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