Role of Heparanase Urinary Level in Type 2 Diabetic Patients with and without Nephropathy.
Amer, F., Mostafa, T., Bessa, S., Elgamal, D. (2023). Role of Heparanase Urinary Level in Type 2 Diabetic Patients with and without Nephropathy.. EKB Journal Management System, 46(1), 127-137. doi: 10.21608/djs.2023.199946.1091
Fatma Amer; Tarek Mostafa; Sahar Bessa; Doaa Elgamal. "Role of Heparanase Urinary Level in Type 2 Diabetic Patients with and without Nephropathy.". EKB Journal Management System, 46, 1, 2023, 127-137. doi: 10.21608/djs.2023.199946.1091
Amer, F., Mostafa, T., Bessa, S., Elgamal, D. (2023). 'Role of Heparanase Urinary Level in Type 2 Diabetic Patients with and without Nephropathy.', EKB Journal Management System, 46(1), pp. 127-137. doi: 10.21608/djs.2023.199946.1091
Amer, F., Mostafa, T., Bessa, S., Elgamal, D. Role of Heparanase Urinary Level in Type 2 Diabetic Patients with and without Nephropathy.. EKB Journal Management System, 2023; 46(1): 127-137. doi: 10.21608/djs.2023.199946.1091

Role of Heparanase Urinary Level in Type 2 Diabetic Patients with and without Nephropathy.

Delta Journal of Science
Volume 46, Issue 1, February 2023, Page 127-137  XML PDF (648.96 K)
Document Type: Research and Reference
DOI: 10.21608/djs.2023.199946.1091
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Authors
Fatma Amerorcid 1; Tarek Mostafa email orcid 2; Sahar Bessa3; Doaa Elgamal4
1chemistry department faculty of science tanta universiry
2Department of Chemistry, Division of Biochemistry, Faculty of Science, Tanta University,Tanta, Egypt
3Internal Medicine Department, Faculty of Medicine, Tanta University,Tanta,Egypt.
4Chemistry Department, Faculty of Science, Tanta Universiry,Tanta,Egypt
Abstract
End-stage renal disease (ESRD)is caused primarily by diabetic nephropathy (DN), which is the most serious and widespread diabetic kidney complication. The endo—D-glucuronidase heparanase plays a role in the development and progression of DN. sulphate (HS), an extracellular matrix (ECM) component, is particularly degraded by heparanase.The precise mechanism by which heparanase sustains the pathology of DN remains unknown.This study seeks to elucidate the role of heparanase urinary level in type 2 diabetic patients with and without nephropathy, as well as to assess its relationship with various clinical and biochemical parameters.This study involved 55 participants (15 diabetics with normoalbuminuria, 15 with microalbuminuria, 15 with macroalbuminuria and 10 healthy volunteers as a control group).Urinary heparanase levelwas measured.It was significantly greater in patients with DN than in control subjects.The ratio of urinary albumin to creatinine was inversely correlated with the glomerular filtration rate, while it was positively correlated with the estimated glomerular filtration rate(e GFR).In type 2 diabetic patients, the urinary heparanase level can serve as a diagnostic biomarker for DN.
Keywords
Key Words: Heparanase; Heparan sulphate; Diabetic nephropathy; end-stage renal disease
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