The Impact of Alpha-lipoic acid on the Monosodium Glutamate Induced Motor Coordination Dysfunction in Rats | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 36, Volume 91, Issue 1, April 2023, Page 4001-4010 PDF (643.01 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2023.294167 | ||||
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| Authors | ||||
| Safaa M. Saleh; Gerges S. Yousef; Suzan A. Khodir; Amany F. Elziat; Ghana S. Amer | ||||
| Abstract | ||||
| Background: Monosodium Glutamate (MSG) is one of the most commonly used flavors that may lend to motor incoordination. Alpha-lipoic acid (ALA) has antioxidant and anti-inflammatory effects with neuro-protective effects. Objectives: Present work aimed to elucidate possible protective potential of ALA on the motor incoordination induced by MSG and the possible underlying mechanisms. Materials and Methods: Seventy male Wister albino rats were randomized into five groups: 1-Control group (10 rats). 2-MSG group (20 rats): MSG 3 wks and MSG 6 wks ten rats each. 3-ALA pretreated group (10 rats). 4-ALA cotreated group (20 rats): ALA cotreated 3 wks and ALA cotreated 6 wks ten rats each. 5-Alpha-Lipoic acid-post- group. Thereafter, motor coordination assessed using Rotarod and Footprint analysis were assessed in addition to serum Malondialdehyde (MDA), total antioxidant capacity (TAC), Tumor necrosis factor- alpha (TNF- α), cerebellar brain derived neurotrophic factor (BDNF) and Oxidative DNA damage were measured. Also, histo-pathological examination of cerebellar tissue was performed and number of purkinjie cells was assessed. Results: ALA resulted in better improvement for MSG-induced motor incoordination, oxidative impairment and microscopic alterations of cerebellar architecture in cotreated group than that of post-treated group, with insignificant change in pretreated group. Conclusion: ALA exhibit protective effect against motor incoordination, oxidative stress and cerebellar damage induced by MSG toxicity best as cotreatment, less when used as post-treatment but this effect useless as pretreatment. | ||||
| Keywords | ||||
| Alpha-lipoic acid; BDNF and oxidative DNA damage; motor incoordination; MSG | ||||
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