COMPARISON BETWEEN THE MANAGEMENT AND OUTCOME OF TYPICAL AND ATYPICAL ANTIPSYCHOTIC DRUGS OVERDOSE: A STUDY FROM THE NATIONAL ENVIRONMENTAL AND CLINICAL TOXICOLOGY RESEARCH CENTRE, CAIRO UNIVERSITY HOSPITALS | ||||
The Egyptian Journal of Forensic Sciences and Applied Toxicology | ||||
Volume 23, Issue 1, March 2023, Page 111-119 PDF (397.38 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejfsat.2023.177423.1282 | ||||
View on SCiNiTO | ||||
Authors | ||||
ahmed ahmed fathy1; eman zohairy1; Nevine khairy El Kady 2; Iman Abdolmoneim Abdelrasheed3; Amani Abdel Fattah 4 | ||||
1Forensic and clinical toxicology department, Faculty of medicine, Cairo University | ||||
2forensic and clinical toxicology department, faculty of medicine, Cairo University, Cairo, Egypt. | ||||
3pharmacology department kasr alainy cairo University | ||||
4Forensic and Clinical Toxicology department, Faculty of Medicine, Cairo University | ||||
Abstract | ||||
Objectives: The purpose of this study was to assess the effect of management on the outcome of antipsychotic drugs overdose in Egypt. Methodology: This study was conducted on 75 cases presented to National Environmental and Clinical Toxicology research Centre, Cairo university hospitals with antipsychotic medications toxicity, from April 2018 to September 2018. Results: The most common presenting age group was age group B; from 18-40 years (45.3%), females (68%), belonging to urban population (82.7%), educated (96.2%) and not working (89.3%). The majority of cases presented with abnormal CNS manifestation; altered conscious level (97.3%), abnormal pulse; tachycardia (98.7%) and abnormal pupil size; mydriasis or miosis (52%). Most of the cases did not do drug screening (98.7%), neither did decontamination (66.7%) nor receive antidote (100%), but most of them received supportive measures. Most of the cases were admitted (90.7%) and stayed in hospital more than 24 hours and less than one week. Regarding the outcome, most of the cases were cured (92.6%). | ||||
Keywords | ||||
Antipsychotic Medications; Toxicity; management; Outcome | ||||
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