Serum Osteoprotegerin (OPG) as a Potential Biomarker for Disease Activity in Ulcerative Colitis | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 45, Volume 91, Issue 1, April 2023, Page 4972-4977 PDF (573.79 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2023.294345 | ||||
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| Authors | ||||
| Ahmed Ahmed Al-said Ibrahim; Gasser Ibrahim El-Azab; Naglaa Allam Ahmed Allam; Mona Mahmoud Hassouna; Ahmed Mohamed Edrees | ||||
| Abstract | ||||
| Background: Inflammation and ulceration of the intestinal mucosa occur repeatedly in patients with ulcerative colitis (UC), leading to numerous bouts of bleeding per rectum. Objective: To evaluate serum osteoprotegerin (OPG) level in cases who had ulcerative colitis and its correlation with disease activity. Patients and Methods: This case control was conducted at the National Liver Institute, Menoufia University on 89 patients. They were divided into two groups and were matched in age and gender: Group I: 50 patients with ulcerative colitis diagnosed utilizing colonoscopy and histopathological examination. Group II: 39 individuals who had normal colonoscopic findings (grossly and histopathologically) as a control group. Results: Differences in OPG readings between the control group and UC subgroups were statistically significant. The mean OPG level in patients with extraintestinal manifestations (EIM) was 596 ± 365 pg/ml, while the mean OPG level in patients without EIM was 384 ± 333 pg/ml. OPG levels were not significantly linked to the prevalence of extraintestinal symptoms. The concentration of OPG was positively correlated with disease severity. Conclusion: The present study suggested that serum osteoprotegerin can be considered as a novel biomarker for assessing ulcerative colitis activity. | ||||
| Keywords | ||||
| Osteoprotegerin (OPG); Biomarker; Ulcerative Colitis | ||||
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