The Novel Modified 5-Fluorouracil with Zinc Oxide Nano-Particles and its Combined Effect with Gamma Radiations on Human Cancer Cell Lines
Hassan, N., El-Dessouky, M., Salah Eldin, A., Korraa, S., Elgazzar, E., Badawi, A. (2022). The Novel Modified 5-Fluorouracil with Zinc Oxide Nano-Particles and its Combined Effect with Gamma Radiations on Human Cancer Cell Lines. EKB Journal Management System, 35(1), 145-155. doi: 10.21608/ejrsa.2023.193748.1150
N. A. Hassan; M.A. El-Dessouky; A.M. Salah Eldin; S.S. Korraa; Eman M. Elgazzar; A.M. Badawi. "The Novel Modified 5-Fluorouracil with Zinc Oxide Nano-Particles and its Combined Effect with Gamma Radiations on Human Cancer Cell Lines". EKB Journal Management System, 35, 1, 2022, 145-155. doi: 10.21608/ejrsa.2023.193748.1150
Hassan, N., El-Dessouky, M., Salah Eldin, A., Korraa, S., Elgazzar, E., Badawi, A. (2022). 'The Novel Modified 5-Fluorouracil with Zinc Oxide Nano-Particles and its Combined Effect with Gamma Radiations on Human Cancer Cell Lines', EKB Journal Management System, 35(1), pp. 145-155. doi: 10.21608/ejrsa.2023.193748.1150
Hassan, N., El-Dessouky, M., Salah Eldin, A., Korraa, S., Elgazzar, E., Badawi, A. The Novel Modified 5-Fluorouracil with Zinc Oxide Nano-Particles and its Combined Effect with Gamma Radiations on Human Cancer Cell Lines. EKB Journal Management System, 2022; 35(1): 145-155. doi: 10.21608/ejrsa.2023.193748.1150

The Novel Modified 5-Fluorouracil with Zinc Oxide Nano-Particles and its Combined Effect with Gamma Radiations on Human Cancer Cell Lines

Egyptian Journal of Radiation Sciences and Applications
Volume 35, Issue 1, December 2022, Page 145-155  XML PDF (1.18 MB)
Document Type: Original Article
DOI: 10.21608/ejrsa.2023.193748.1150
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Authors
N. A. Hassan1; M.A. El-Dessouky2; A.M. Salah Eldin2; S.S. Korraa3; Eman M. Elgazzar email orcid 1; A.M. Badawi4
11Health Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt
2Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
3Health Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt
4Applied Surfactant Laboratory, Egyptian Petroleum Research Institute, Nasr City, Cairo, Egypt
Abstract
Background: 5-Fluorouracil (5-FU) is widely used in the treatment of cancer. The clinical use of 5-Flurouracil is constantly challenged by its poor selectivity and various side effects. Aim: The modification of 5-fluorouracil with Zinc oxide nanoparticles (NPs) and Cetrimonium bromide (CTAB) to enhance its antitumor activity was carried out. Material and Methods: The nanocomposite synthesis was evident by Scanning Electron Microscope (SEM) analysis, Transmission Electron Microscopy (TEM) analysis, X-Ray Diffraction (XRD) analysis and Fourier Transforms Infrared (FT-IR) spectroscopy. In addition to that the combined effect of ionizing gamma radiation with the modified 5-FU with Zinc oxide nanoparticles and Cetrimonium bromide (CTAB) was also investigated after 24 and 48 hr. The in vitro anticancer activity of nanocomposite (5-FU modified with Zinc oxide nano particles and CTAB) on liver cancer cells lines (HepG2), (HUH-7) and breast cancer cells (MCF-7) was investigated using MTT (3-4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay after 24 and 48 hr. Results: Nanocomposite exerted better in vitro anticancer activity against the previous human cancer cell lines comparable to the activity of 5-FU alone after 24 and 48 hr.
Conclusions: The effectiveness of 5-FU modified with Zinc oxide nanoparticles and CTAB as an antitumor drug is enhanced by the combination of Chemotherapy and Radiotherapy with Nanotechnology.
Keywords
5-Fluorouracil; Antitumor activity; Cetrimonium bromide; Human cancer cell lines; Zinc oxide nanoparticles
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