Pregnancy-Associated Placental Protein A2/Placental Growth Factor Ratio Might Discriminate Normotensive Pregnant Women Who Are Liable to Develop Early-Onset Preeclampsia

Abdel Raziq, Heba E.; Khalil, Amira E.; Alnoury, Hamasat A; Morcos, George N.B.; Kamel, Moataz Maher

doi:10.21608/ejchem.2023.187983.7467

	Pregnancy-Associated Placental Protein A2/Placental Growth Factor Ratio Might Discriminate Normotensive Pregnant Women Who Are Liable to Develop Early-Onset Preeclampsia
Egyptian Journal of Chemistry
Volume 66, Issue 13, December 2023, Page 371-377 PDF (863.51 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.187983.7467
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Authors
Heba E. Abdel Raziq¹; Amira E. Khalil¹; Hamasat A Alnoury ²^{, 3}; George N.B. Morcos⁴^{, 3}; Moataz Maher Kamel⁴^{, 3}
¹Department of Obstetrics & Gynecology, Faculty of Medicine, Benha University.
²Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University.
³Basic Medical Science Department, Faculty of Medicine, King Salman International University, South Sinai, Egypt.
⁴Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Abstract
Abstract Objectives: Evaluation of the ability of serum Pregnancy-associated Placental Protein A2 (PAPP-A2), Placental growth factor (PLGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) levels estimated at the 12th gestational weeks (GW) to predict the possibility of development of preeclampsia (PE) in the normotensive pregnant women. Patients: 66 PE and 66 No-PE women gave blood samples at the 12th GW for ELISA estimation of study biomarkers. During pregnancy, 21 women had early-onset and 19 women had severe PE. Study outcome is the ability of serum cytokines' levels estimated at the 12th GW for prediction of oncoming PE development. Results: Blood pressure (BP) measures were significantly higher in PE women than their baseline measures and corresponding measures of women of No-PE group. Serum levels of PAPP-A2 and sFlt-1 were significantly higher, while levels of PLGF were significantly lower in PE than in No-PE women. ROC curve analysis defined PAPP-A2/PLGF ratio >0.51 as discriminator point for early-onset PE with moderate accuracy (AUC=0.662; 95% CI: 0.264-0.982) and sensitivity rate of 90.48% and negative predictive value of 94.12%. Conclusion: Determination of PAPP-A2/PLGF ratio in serum at the 12 GW might be used as early predictor for PE and ratio at >0.51 could predict early-onset PE with moderate accuracy. Keywords: Preeclampsia, Early-onset, Pregnancy-associated placental protein A2, Placental growth factor, Soluble fms-Like Tyrosine Kinase-1, Early predictors
Keywords
hypertension with pregnancy; prediction; Pregnancy-associated placental protein A2; Placental growth factor; Soluble fms-Like Tyrosine Kinase-1


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