Effectiveness and Pregnancy Outcomes of COVID-19 Vaccination in Pregnancy

Ismail Heraiz, Ahmed; Zaitoun, Mohamed Moustafa; Gad, Abdalla Hassan; Frere, Noha Osman; Zaitoun, Nahla A.; Soliman, Al Zahraa M.; Nafea, Alaa; Risha, AMR I.; Elshafey, Eslam

doi:10.21608/zumj.2023.199104.2766

	Effectiveness and Pregnancy Outcomes of COVID-19 Vaccination in Pregnancy
Zagazig University Medical Journal
Article 15, Volume 29, Issue 4, July and August 2023, Page 1092-1098 PDF (356.1 K)
Document Type: Original Article
DOI: 10.21608/zumj.2023.199104.2766
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Authors
Ahmed Ismail Heraiz ¹; Mohamed Moustafa Zaitoun ²; Abdalla Hassan Gad³; Noha Osman Frere ⁴; Nahla A. Zaitoun ⁵; Al Zahraa M. Soliman ⁶; Alaa Nafea⁷; AMR I. Risha⁷; Eslam Elshafey⁸
¹Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University
²Lecturer of Obstetrics & Gynecology , Department, Faculty of Medicine, Zagazig University, Zagazig
³Lecturer of obstetrics and gynecology, Faculty of Medicine, Zagazig University hospitals
⁴Lecturer of Family Medicine Department, Zagazig University , Zagazig, Egypt
⁵Family Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
⁶Lecturer of Public health and community medicine, faculty of medicine, Zagazig University
⁷Pediatrics Department, Faculty of Medicine, Zagazig University
⁸Clinical Pathology Department, Al-Ahrar Zagazig Teaching Hospital
Abstract
Background: Vaccination against COVID-19 during pregnancy is suggested to avoid pregnancy complications morbidity and bad delivery outcomes. However, the safety and efficacy of COVID-19 vaccinations during pregnancy is a specific issue impacting vaccination uptake by this susceptible group due to alterations in immune, respiratory, and cardiovascular physiology that occur during pregnancy. The purpose of this study was to examine the relationship between prenatal mother COVID-19 immunization, pregnancy course, and outcomes. Patients and Methods: A retroactive cohort analysis was conducted on all women who gave birth. Women having a previous COVID-19 diagnosis, numerous pregnancies, or an uncertain vaccination status were excluded. Pregnancy, neonatal problems, and delivery were compared with women who got 1 or 2 doses of a vaccine throughout pregnancy and women who did not get any vaccinations. Using multivariable models, the background characteristics were accounted for. Results: The pregnancy complications were higher in unvaccinated group than vaccinated group with no statistical significant difference except stillbirth that was present only in unvaccinated group (3%). Women who were vaccinated gave birth at a significantly later gestational age. No differences between the groups were detected in terms of postpartum and delivery factors. Women who received vaccination delivered at slightly higher birth weight. No differences were detected in terms of neonatal features and problems between the two groups. Conclusions: We concluded that COVID-19-vaccinated pregnant women experienced similar pregnancy outcomes as unvaccinated pregnant women. In some cases, vaccination proved to be better outcome than un-vaccination.
Keywords
COVID-19; Pregnancy; Vaccination; Prenatal; Outcomes


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