Prognostic value of Isocitrate Dehydrogenase And Mismatch Repair Genes In Gliomas
Ahmed, D., Rashed, H., Mohamed, A., Saeed, N., Elmosalamy, W. (2024). Prognostic value of Isocitrate Dehydrogenase And Mismatch Repair Genes In Gliomas. EKB Journal Management System, 30(1.3), 378-380. doi: 10.21608/zumj.2023.202612.2777
Dina Walid Ahmed; Hayam Elsayed Rashed; Asmaa Hussein Mohamed; Nelly Mohamed Saeed; Wael Abdelrahman Elmosalamy. "Prognostic value of Isocitrate Dehydrogenase And Mismatch Repair Genes In Gliomas". EKB Journal Management System, 30, 1.3, 2024, 378-380. doi: 10.21608/zumj.2023.202612.2777
Ahmed, D., Rashed, H., Mohamed, A., Saeed, N., Elmosalamy, W. (2024). 'Prognostic value of Isocitrate Dehydrogenase And Mismatch Repair Genes In Gliomas', EKB Journal Management System, 30(1.3), pp. 378-380. doi: 10.21608/zumj.2023.202612.2777
Ahmed, D., Rashed, H., Mohamed, A., Saeed, N., Elmosalamy, W. Prognostic value of Isocitrate Dehydrogenase And Mismatch Repair Genes In Gliomas. EKB Journal Management System, 2024; 30(1.3): 378-380. doi: 10.21608/zumj.2023.202612.2777

Prognostic value of Isocitrate Dehydrogenase And Mismatch Repair Genes In Gliomas

Zagazig University Medical Journal
Volume 30, Issue 1.3, March and April 2024, Page 378-380  XML PDF (784.59 K)
Document Type: Review Articles
DOI: 10.21608/zumj.2023.202612.2777
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Authors
Dina Walid Ahmed email 1; Hayam Elsayed Rashed2; Asmaa Hussein Mohamed3; Nelly Mohamed Saeedorcid 3; Wael Abdelrahman Elmosalamy4
1Demonstrator of pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., medicine, Zagazig, Egypt
2Professor of pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
3Lecturer of pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
4Assistant professor of neurosurgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Abstract
Background: Gliomas are considered the most prevalent malignancies of the central nervous system. These tumors are diffusely infiltrative and behave destructively toward the nearby brain tissue. Based on histological grading, gliomas were previously categorized. Histopathology and molecular characteristics are now included in the classification of brain tumors. Glioma prognosis can be predicted, which allows patients to choose an effective course of treatment. It is crucial to look for fresh prognostic indicators in cancer biopsy samples that might indicate prognosis. IDH mutation is a crucial component for the subclass categorization of diffuse gliomas and is just one of many molecular parameters. Significantly, all forms of IDH-mutant gliomas seem to have much better prognosis than malignant diffuse IDH wild type (IDH-wt) gliomas such as glioblastoma. Conclusion: We concluded that IDH1 and MMR genes immunohistochemical expression could help in the prediction of gliomas outcome. More large-scale multicenter investigations are needed to back up our findings.
Keywords
Gliomas; Mismatch; Isocitrate; Dehydrogenase
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