Ameliorative Roles of Vitamins C, E and DMSA on Hepatic Renal Functions in Male Albino Rats.
Mohamed, F., Sarry, K., Amin, A., Ramy, A. (2018). Ameliorative Roles of Vitamins C, E and DMSA on Hepatic Renal Functions in Male Albino Rats.. EKB Journal Management System, 4(1), 23-32. doi: 10.18576/jpac/040104
F. El-Sayed Mohamed; Kh. Abdel – Kgaffar Sarry; Abddou Seleem Amin; A. Mohamed Ramy. "Ameliorative Roles of Vitamins C, E and DMSA on Hepatic Renal Functions in Male Albino Rats.". EKB Journal Management System, 4, 1, 2018, 23-32. doi: 10.18576/jpac/040104
Mohamed, F., Sarry, K., Amin, A., Ramy, A. (2018). 'Ameliorative Roles of Vitamins C, E and DMSA on Hepatic Renal Functions in Male Albino Rats.', EKB Journal Management System, 4(1), pp. 23-32. doi: 10.18576/jpac/040104
Mohamed, F., Sarry, K., Amin, A., Ramy, A. Ameliorative Roles of Vitamins C, E and DMSA on Hepatic Renal Functions in Male Albino Rats.. EKB Journal Management System, 2018; 4(1): 23-32. doi: 10.18576/jpac/040104

Ameliorative Roles of Vitamins C, E and DMSA on Hepatic Renal Functions in Male Albino Rats.

Journal of Pharmaceutical and Applied Chemistry
Volume 4, Issue 1, January 2018, Page 23-32  XML PDF (1.74 MB)
Document Type: Original Article
DOI: 10.18576/jpac/040104
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Authors
F. El-Sayed Mohamed* 1; Kh. Abdel – Kgaffar Sarry* 2; Abddou Seleem Amin* 3; A. Mohamed Ramy* 1
1Zoology Department, Faculty of Science, Sohag University, Sohag, Egypt
2Clinical Pathology Department, Assuit University, Faculty of Veterinary medicine, Assuit, Egypt
3Zoology Department, Faculty of Science, Sohag University, Sohag, Egypt.
Abstract
This study was carried out to estimate the toxic effect of lead acetate on hepatic and renal functions of rats , and the possible ameliorative effect of both vitamin C and E , and their combination with DMSA against lead intoxication . Thirty male albino rats were divided into five groups and administrated the following treatments for six weeks . group 1 received drinking water and served as control; group 2 received 100 ppm lead acetate; group 3 received 100 ppm lead acetate combined with 50 mg/kg b.wt of DMSA (ip) ; group 4 received 100 ppm lead acetate plus 160 mg/kg b.wt of vitamin C combined with 50 mg / kg b.wt of vitamin E; group 5 received in addition to lead acetate both vitamin C and E plus DMSA in the same previous dose . Lead acetate administrated induced a significant decrease in plasma alkaline phosphatase (ALP) , total proteins and plasma albumin , while it induced a significant increase in the plasma level of acid phosphatase (AP) , compared to the control. Significant elevation in the plasma level of urea , total lipids and triglycerides as a result of lead exposed were also observed , compared with control . DMSA , vitamin C combined with vitamin E , and DMSA combined with both vitamin C and E induced a significant elevation in the plasma level of ALP , total proteins and albumin respectively , whereas a significant decrease in the plasma level of AP , urea , total lipids and triglycerides , respectively were observed . Thus , lead acetate induced toxic effect in hepatorenal functions , whereas , administration of DMSA ,vitamin C plus E and also DMSA combined with both vitamins C and E could ameliorate the toxic effect of lead acetate on the kidney function and to somewhat on the liver function .
Keywords
Ameliorative Roles - Vitamins C; E - DMSA - Hepatic Renal Functions - Male Albino Rats
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