Synthesis, Characterization and Antifungal Studies of Transition Metal Complexes of Dimethylketone Thiosemicarba zone with 1, 10-Phenanthroline | ||||
| Journal of Pharmaceutical and Applied Chemistry | ||||
| Volume 4, Issue 1, January 2018, Page 47-55 PDF (810.97 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.18576/jpac/040107 | ||||
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| Authors | ||||
| Kpomah B* 1; Kpomah D* 2 | ||||
| 1Chemistry Department, Delta State College of Education, Mosogar, Nigeria. | ||||
| 2Biochemistry Department, Federal University Otuoke, Bayelsa State, Nigeria. | ||||
| Abstract | ||||
| Dimethylketone thiosemicarbazones (DMKT);a Schiff base ligand was synthesized by simple condensation reaction between propan-2-one and thiosemicarbazide, the reaction was carried out in the presence of hydrochloricacid. 1,10-phenanthroline (phen) was introduced as a second ligand and the basic coordination chemistry of the mixed ligand with copper(II), zinc(II) andiron(III) were explored. The derivatised DMKT alongside the mixed ligand metal complexes were characterized by Elemental Analysis (EA)and various spectroscopic techniques such as Fourier Transform Infrared (FT-IR), UV/visible and Nuclear Magnetic Resonance (1H-NMR).They were also screened for their antifungal activities against four pathogenic fungi: Aspergillusniger, Penicillium species, Rhizopus and Candida albicans using disc diffusion method. The antifungal studies of the present complexes show that they are good antifungal agents. | ||||
| Keywords | ||||
| Synthesis; Characterization; Antifungal Studies; Transition Metal Complexes; Dimethylketone Thiosemicarba zone | ||||
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