Prospective Ameliorative Activity of Neem (Azadirachta Indica) on Iron Oxide Nanoparticle-Induced Multiple Organ Injury via Attenuating TNF-α Pathway
amin, R., Abd Elaliem, N., Abdeen, A., Ibrahim, S., Elsafty, M., Beder, E. (2023). Prospective Ameliorative Activity of Neem (Azadirachta Indica) on Iron Oxide Nanoparticle-Induced Multiple Organ Injury via Attenuating TNF-α Pathway. EKB Journal Management System, 44(1), 55-60. doi: 10.21608/bvmj.2023.189946.1636
radwa Amin amin; Nabila Mahmoud Abd Elaliem; Ahmed Abdel Hafez Abdeen; Samar Saber Ibrahim; Moamen Hussien Elsafty; Ebtssam Gamal Beder. "Prospective Ameliorative Activity of Neem (Azadirachta Indica) on Iron Oxide Nanoparticle-Induced Multiple Organ Injury via Attenuating TNF-α Pathway". EKB Journal Management System, 44, 1, 2023, 55-60. doi: 10.21608/bvmj.2023.189946.1636
amin, R., Abd Elaliem, N., Abdeen, A., Ibrahim, S., Elsafty, M., Beder, E. (2023). 'Prospective Ameliorative Activity of Neem (Azadirachta Indica) on Iron Oxide Nanoparticle-Induced Multiple Organ Injury via Attenuating TNF-α Pathway', EKB Journal Management System, 44(1), pp. 55-60. doi: 10.21608/bvmj.2023.189946.1636
amin, R., Abd Elaliem, N., Abdeen, A., Ibrahim, S., Elsafty, M., Beder, E. Prospective Ameliorative Activity of Neem (Azadirachta Indica) on Iron Oxide Nanoparticle-Induced Multiple Organ Injury via Attenuating TNF-α Pathway. EKB Journal Management System, 2023; 44(1): 55-60. doi: 10.21608/bvmj.2023.189946.1636

Prospective Ameliorative Activity of Neem (Azadirachta Indica) on Iron Oxide Nanoparticle-Induced Multiple Organ Injury via Attenuating TNF-α Pathway

Benha Veterinary Medical Journal
Volume 44, Issue 1, April 2023, Page 55-60  XML PDF (1.91 MB)
Document Type: Original Article
DOI: 10.21608/bvmj.2023.189946.1636
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Authors
radwa Amin amin email orcid 1; Nabila Mahmoud Abd Elaliemorcid 2; Ahmed Abdel Hafez Abdeenorcid 2; Samar Saber Ibrahimorcid 2; Moamen Hussien Elsafty3; Ebtssam Gamal Beder2
1Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Egypt. Menoufia University Hospital, Faculty of Veterinary Medicine, Sadat City University, Egypt.
2Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Egypt.
3Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Egypt.
Abstract
Neem trees (Azadirachta indica) have received a lot of academic interest recently because of their strong antioxidant and anti-proliferative capabilities. In this study, we evaluated the potential alleviating effect of neem on Fe2O3 NP -induced damage in brain, heart, and testis. Twenty-eight male albino rats were divided into four equal groups at random. The control group was given D.W orally for 45 days, Neem group was given 200 mg/kg/day orally for 45 days, Fe2O3 NP group was given 60 mg/kg of Fe2O3 NP I/P at the 31th-45th day, Fe2O3 NP +Neem group was given 200 mg/kg day of neem orally for 45 days + 60 mg/kg of Fe2O3 NP IP at the 31th–45th day. In the present investigation, histopathological examination of brain, heart, and testis sections revealed cellular degeneration and necrosis after Fe2O3 NP exposure. Also, TNF-α expressions were considerably elevated. Neem pr-treatment maintain tissue architecture in Fe2O3 NP-intoxicated rats. Our findings proved that neem have a potential protective impact against cellular damage induced by Fe2O3 NP through its anti-inflammatory, antiapoptotic, and antioxidant effects.
Keywords
Fe2O3 NP; Neem; Histopathology; Immunohistochemistry
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