Role of Oral Lactoferrin in Prevention of Recurrent Bacterial Vaginosis in Third Trimester of Pregnancy
Alanwar, A., Ezzat, R., Gerges, M., Al Barhami, K., Ibrahim, S. (2023). Role of Oral Lactoferrin in Prevention of Recurrent Bacterial Vaginosis in Third Trimester of Pregnancy. EKB Journal Management System, 91(1), 4368-4372. doi: 10.21608/ejhm.2023.296394
Amal Mohamed Alanwar; Rania S. Ezzat; Marian Asaad Gerges; Khoulh Al Mahdi Anbeeh Al Barhami; Safaa Abd El salam Ibrahim. "Role of Oral Lactoferrin in Prevention of Recurrent Bacterial Vaginosis in Third Trimester of Pregnancy". EKB Journal Management System, 91, 1, 2023, 4368-4372. doi: 10.21608/ejhm.2023.296394
Alanwar, A., Ezzat, R., Gerges, M., Al Barhami, K., Ibrahim, S. (2023). 'Role of Oral Lactoferrin in Prevention of Recurrent Bacterial Vaginosis in Third Trimester of Pregnancy', EKB Journal Management System, 91(1), pp. 4368-4372. doi: 10.21608/ejhm.2023.296394
Alanwar, A., Ezzat, R., Gerges, M., Al Barhami, K., Ibrahim, S. Role of Oral Lactoferrin in Prevention of Recurrent Bacterial Vaginosis in Third Trimester of Pregnancy. EKB Journal Management System, 2023; 91(1): 4368-4372. doi: 10.21608/ejhm.2023.296394

Role of Oral Lactoferrin in Prevention of Recurrent Bacterial Vaginosis in Third Trimester of Pregnancy

The Egyptian Journal of Hospital Medicine
Article 90, Volume 91, Issue 1, April 2023, Page 4368-4372  XML PDF (385.25 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2023.296394
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Authors
Amal Mohamed Alanwar; Rania S. Ezzat; Marian Asaad Gerges; Khoulh Al Mahdi Anbeeh Al Barhami email ; Safaa Abd El salam Ibrahim
Abstract
Background: One of the most common conditions affecting women's health throughout the childbearing years is bacterial vaginosis (BV), which have a negative impact on pregnancy. Nutraceutical proteins and probiotics (such as lactoferrin) can help restore the equilibrium of the vaginal microbiome, which can be of significant use in avoiding unfavorable pregnancy outcomes. Aim of Study: This study aimed to evaluate the efficacy of lactoferrin in prevention of recurrent bacterial vaginosis in third trimester singleton pregnancy.
Patients and method: This was randomized controlled clinical trial conducted at Obstetrics and Gynecology Department, Zagazig University, Outpatient Clinic. The study included 66 cases with history of receurent bacterial vaginosis divided into two groups: Study group that received lactoferrin  oral consumption of 2 capsules/day for 5 days, then 10 consecutive days at the dosage of 1 capsule/day (pravotinR). Control group, which did not receive lactoferrin. All of the ladies took 1 capsule of lactoferrin or a placebo daily for 10 days straight each month during the follow-up period.
Results: There was significant differences in microbiological cure rate as detected by Nugent scores in studied  groups at T1 and T2 where the study group had microbiological cure rate than control one (57.6% and 9.1%) versus (72.7% and 18%) respectively. Low APGAR1, preterm, CS delivery type, LBW and PROM were significantly higher with control group.
Conclusion: Repeated sessions of orally delivered probiotics in conjunction with lactoferrin are beneficial in preventing BV recurrences, as evidenced by much greater clinical and microbiological cure rates, as well as a favourable safety profile.
 
 
Keywords
Bacterial vaginosis; Prevention; Lactoferrin
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