Predictive Value of Neutrophil to Lymphocyte Ratio Combined with C-Reactive Protein for Diagnosis of Spontaneous Bacterial Peritonitis among Cirrhotic Patients
Elhendawy, R., Elghoneimy, S., Elnemr, S., Salem, A., Abdelkader, A. (2023). Predictive Value of Neutrophil to Lymphocyte Ratio Combined with C-Reactive Protein for Diagnosis of Spontaneous Bacterial Peritonitis among Cirrhotic Patients. EKB Journal Management System, 91(1), 4380-4386. doi: 10.21608/ejhm.2023.296396
Ramy I. Elhendawy; Salama M. Elghoneimy; Sahar A. Elnemr; Aya A. Salem; Abeer H. Abdelkader. "Predictive Value of Neutrophil to Lymphocyte Ratio Combined with C-Reactive Protein for Diagnosis of Spontaneous Bacterial Peritonitis among Cirrhotic Patients". EKB Journal Management System, 91, 1, 2023, 4380-4386. doi: 10.21608/ejhm.2023.296396
Elhendawy, R., Elghoneimy, S., Elnemr, S., Salem, A., Abdelkader, A. (2023). 'Predictive Value of Neutrophil to Lymphocyte Ratio Combined with C-Reactive Protein for Diagnosis of Spontaneous Bacterial Peritonitis among Cirrhotic Patients', EKB Journal Management System, 91(1), pp. 4380-4386. doi: 10.21608/ejhm.2023.296396
Elhendawy, R., Elghoneimy, S., Elnemr, S., Salem, A., Abdelkader, A. Predictive Value of Neutrophil to Lymphocyte Ratio Combined with C-Reactive Protein for Diagnosis of Spontaneous Bacterial Peritonitis among Cirrhotic Patients. EKB Journal Management System, 2023; 91(1): 4380-4386. doi: 10.21608/ejhm.2023.296396

Predictive Value of Neutrophil to Lymphocyte Ratio Combined with C-Reactive Protein for Diagnosis of Spontaneous Bacterial Peritonitis among Cirrhotic Patients

The Egyptian Journal of Hospital Medicine
Article 92, Volume 91, Issue 1, April 2023, Page 4380-4386  XML PDF (588.21 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2023.296396
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Authors
Ramy I. Elhendawy; Salama M. Elghoneimy; Sahar A. Elnemr; Aya A. Salem email ; Abeer H. Abdelkader
Abstract
Background: A serious problem for cirrhotic individuals is spontaneous bacterial peritonitis (SBP). Clinical significance of SBP's C-reactive protein (CRP) as well as neutrophil-to-lymphocyte ratio (NLR) have been discovered using varying threshold levels. Objective: The aim of the current work was to assess the validity of diagnostic paracentesis with the use of combined blood NLR and CRP as a non-invasive predictor for early diagnosis of SBP.
Patients and Methods: This case control study included a total of 60 cirrhotic decompensated patients, admitted at Department of Tropical Medicine, Zagazig University Hospitals. Patients were categorized into two groups (30 each) according to neutrophil count in Ascitic fluid; Group I with SBP and Group II free from SBP. Both NLR and CRP were assessed among all subjects.
Results: NLR was statistically significant higher in SBP group. A cut-off value of blood NLR >2.9 on ROC curve had a specificity of 88% as well as sensitivity of 95% for SBP diagnosis in cirrhotic patients. CRP level differed significantly among cirrhotic patients diagnosed with SBP. A cut-off >15 mg/L had a sensitivity and specificity of 85% and 90 % respectively in diagnosing SBP in cirrhotic patients. Combination NLR and CRP had a cut-off >22.6 mg/L, had a sensitivity and specificity of 86%, 91 % respectively in SBP diagnosis among cirrhotic patients.
Conclusions: Combined NLR and CRP with cut of >2.9, and >15 mg/dl respectively could be used as a novel, non-invasive predictor for SBP diagnosis.
 
Keywords
Spontaneous Bacterial Peritonitis; NLR; CRP
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