Measurement of Interleukin-1β Level in Gingival Crevicular Fluid in Periodontitis Patients Treated by Non-Surgical Periodontal Therapy Combined with Topical Application of Melatonin Gel | ||||
| Al-Azhar Assiut Dental Journal | ||||
| Article 6, Volume 6, Issue 1, April 2023, Page 55-62 PDF (1.13 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/aadj.2023.296420 | ||||
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| Authors | ||||
Ibrahim Hammad Ibrahim  1; Ahmed M. Ali2; Khaled M. Afify3; Bahaa Badr4
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| 1Department of Oral medicine, Periodontology, Diagnosis and Oral radiology, Faculty of Dental Medicine, (Assiut, boys), Al-Azhar University, Egypt. | ||||
| 2Department of Oral medicine, Periodontology, Diagnosis and Oral radiology, Faculty of Dental Medicine, (Assiut, boys), Al-Azhar University, Egypt | ||||
| 3Department of Oral pathology, Faculty of Dental Medicine, (Assiut, boys), Al-Azhar University, Egypt. | ||||
| 4Department of microbiology and immunology, Faculty of Medicine, (Assiut), Al-Azhar University, Egypt. | ||||
| Abstract | ||||
| Aim: The present study was performed to evaluate the efficacy of topical application of melatonin gel on clinical parameter and biochemical level of IL-1-β in gingival crevicular fluid in patients with periodontitis treated by non-surgical periodontal therapy. Subjects and methods: In this study, forty periodontitis patients with stage І, П grade A, were divided randomly into two groups: Group І: Twenty periodontitis patients with stage І, II grade A treated with conventional periodontal treatment (scaling and root planing) combined with intra pocket application of 2% melatonin gel. Group < /div> П: Twenty periodontitis patients with stage І,II grade A treated with conventional periodontal treatment alone (scaling and root planing). All patients were evaluated clinically at; base line and after 3 and 6 months. Also, biochemical evaluation of IL-1β using ELISSA at; base line and after 2 weeks, 1and 3 months. Results of the present study were recorded, tabulated and statistically analyzed. Results: clinical findings showed a statistically significant difference in all groups at the different intervals when compared to the baseline, biochemical evaluation of IL-1β was a statistically significant difference between group I and group II at 2 weeks and after 1 month only during the period of application. Conclusion: Adjunctive use of topically applied melatonin gel 2% appeared to be has beneficial effect on both clinical and biochemical parameters in patients with stage І, П, grade A periodontitis, with a statistically significant difference between group I and group II at 2 weeks and after 1 month of treatment (during the period of melatonin application) however, this effect is not significant when compared with scaling and root planning alone after 3 months of treatment | ||||
| Keywords | ||||
| Melatonin gel 2%; Periodontitis; gingival crevicular fluid; biochemical level | ||||
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