Association between interleukin-22 genetic polymorphism and colon cancer risk in Egyptian patients
El-Emam, O., Fahmi, M., Ghobrial, F., Abdel Haleem, R., El-Mahdy, R., el Wassefy, M. (2023). Association between interleukin-22 genetic polymorphism and colon cancer risk in Egyptian patients. EKB Journal Management System, 40(2), 405-410. doi: 10.21608/bmfj.2023.185605.1767
Ola Ali El-Emam; Maryan Waheeb Fahmi; Fady Emil Ghobrial; Rania Talaat Abdel Haleem; Rasha El-Mahdy; Mona el Wassefy. "Association between interleukin-22 genetic polymorphism and colon cancer risk in Egyptian patients". EKB Journal Management System, 40, 2, 2023, 405-410. doi: 10.21608/bmfj.2023.185605.1767
El-Emam, O., Fahmi, M., Ghobrial, F., Abdel Haleem, R., El-Mahdy, R., el Wassefy, M. (2023). 'Association between interleukin-22 genetic polymorphism and colon cancer risk in Egyptian patients', EKB Journal Management System, 40(2), pp. 405-410. doi: 10.21608/bmfj.2023.185605.1767
El-Emam, O., Fahmi, M., Ghobrial, F., Abdel Haleem, R., El-Mahdy, R., el Wassefy, M. Association between interleukin-22 genetic polymorphism and colon cancer risk in Egyptian patients. EKB Journal Management System, 2023; 40(2): 405-410. doi: 10.21608/bmfj.2023.185605.1767

Association between interleukin-22 genetic polymorphism and colon cancer risk in Egyptian patients

Benha Medical Journal
Article 9, Volume 40, Issue 2, September and October 2023, Page 405-410  XML PDF (501.26 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2023.185605.1767
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Authors
Ola Ali El-Emam email orcid 1; Maryan Waheeb Fahmi2; Fady Emil Ghobrial3; Rania Talaat Abdel Haleem4; Rasha El-Mahdy5; Mona el Wassefy6
1Clinical pathology department, faculty of medicine,Mansoura university, Egypt
2medical oncology, faculty of medicine, mansoura university, mansoura, Egypt
3Medical Oncology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
4Medical Microbiology and Immunology Department, Faculty of Medicine, Helwan University, Egypt
5Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
6Immunology unit Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Abstract
Background: The cytokine interleukin-22 (IL-22) is produced by T cells and natural killer cells and is associated with tumorigenesis and tumor progression. Unlike most cytokines, the main impact of IL-22 is on non-hematopoietic epithelial cells and fibroblasts in tissues as lung, liver, kidney, thymus, pancreas, breast, gut, skin and synovium. Several (SNPs) have previously been identified in the IL-22 gene as (−429C/T, +1995 A/C and +1046 T/A).
Aim: This study aimed to investigate the association of IL-22 polymorphisms with the colon cancer risk in Egyptian population in relation to tumor staging.
Subject and method: A prospective center-based case-control study comprising 100 patients with pathologically proven colon cancer attending Mansoura oncology center from Jan 2017 till Jan 2019 and 100 age and gender-matched healthy controls.
Real time PCR with TaqMan probes was used to determine the genotypes of -429 C/T.
Results: A significant association was found between CT, TT, CT+TT genotypes, and T allele with the risk of cancer colon. Unfortunately, we did not find any statistically significant difference between IL 22 different genotypes of cases regarding sex, gender, tumor size, albumin, CA 19.9 (P=0.570) or age (P 0.993).
Conclusion: up to the authors’ knowledge, this is the first report recording that the IL-22 -429 C/T gene polymorphism is associated with colon cancer risk in Egyptian patients., Also our findings suggested that the IL-22 −429C/T gene polymorphisms might be associated with colon cancer in Egyptian population. Further studies are necessary to confirm our results.
Keywords
Interleukin- 22; -429C/T; rs2227485; single nucleotide polymorphism; cancer colon
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