Unexpected Products of the Reaction of Cyanoacetylhydrazones of Aryl/heteryl Ketones with Hydrazine: A New Route to Aryl/Heteryl Hydrazones, X-ray Structure, and In vitro Anti-proliferative Activity Against NCI 60-cell Line Panel | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 66, Issue 13, December 2023, Page 225-239 PDF (2.49 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2023.197330.7682 | ||||
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| Authors | ||||
Reham A. Mohamed-Ezzat   1; Benson M. Kariuki 2; Galal H. Elgemeie 3
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| 1Chemistry of Natural & Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Center, Cairo, 12622, Egypt | ||||
| 2School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK | ||||
| 3Department of Chemistry, Faculty of Science, Helwan University, Cairo, 11795, Egypt. | ||||
| Abstract | ||||
| A new unexpected synthetic non-catalytic method for the synthesis of novel heteryl hydrazones for base-modification of nucleoside analogs has been developed. Characterizations of the products have been performed using NMR spectroscopy and single crystal x-ray diffraction analysis. Further in vitro anti-proliferative potency of the compounds against NCI 60 cell lines has been estimated. The results indicate anti-cancer activity by the compounds against several of the cancer cell lines. | ||||
| Keywords | ||||
| Crystal; x-ray; hydrazons; heteryl hydrazons; in vitro anti-proliferative activity | ||||
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