Prevalence of Herpes Simplex Virus in Pregnant Women in Ismailia City | ||||
| Advances in Environmental and Life Sciences | ||||
| Article 4, Volume 4, Issue 1, May 2023, Page 43-51 PDF (294.2 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/aels.2023.204949.1031 | ||||
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| Author | ||||
Shimaa Abbas Shihata Hassan 
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| Botany and Microbiology department, faculty of science, suez canal university, ismailia , egypt | ||||
| Abstract | ||||
| Abstract Introduction: Herpes simplex virus infections are usually asymptomatic, however infection during pregnancy is life-threatening for pregnant women and their newborns. Objectives: We aimed to assess both the seroprevalence of herpes simplex virus type 1 and 2 among pregnant women in Ismailia City as well as the impact of pregnancy duration on their prevalence. Methods: A descriptive cross-sectional study was conducted on 94 serum samples of pregnant women in Ismailia City. The presence of herpes simplex virus type 1 and 2 antibodies (IgG and IgM) and viremia were evaluated by commercial ELISA and (RT-PCR) techniques. Results: Our findings revealed high frequency of HSV-1 and 2 infections among the studied cases with percentages of 74.5% and 98.9%, respectively. Upon the interpretation of the HSV serological profiles, the past latent infection with HSV-1 and 2 were the most prevalent types of infection representing 74.5% and 92.5%, respectively, followed by HSV-2 recurrent infection which was more prevalent (6.4%) than HSV-1 recurrent infection (0%), and no primary infection was found. HSV-2 co-infection was detected in all the HSV-1 positive cases (n= 70, 74.5%). Moreover, there was no correlation between pregnancy duration and HSV-1 and 2 seroprevalences. In addition, the real-time PCR confirmed the positivity of the HSV-2 IgM subjects (n=6), while ruling out the equivocal sample as HSV-2 IgM negative. Conclusion: Pregnancy screening for herpes simplex viruses is recommended to control the high viral seropositivity found among pregnant women in Ismailia City. Furthermore, the real-time PCR technique improves the diagnostic value of serological tests. | ||||
| Keywords | ||||
| Herpes simplex virus type 1; Herpes simplex virus type 2; Pregnant women; Seroprevalence | ||||
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