Prognostic Value of Ascitic Neutrophil Gelatinase-Associated Lipocalin in Decompensated Liver Cirrhosis with Spontaneous Bacterial Peritonitis Patients
Hassan, R., Salem, G., Mohamed, B., Zidan, A., El-Gebaly, A. (2023). Prognostic Value of Ascitic Neutrophil Gelatinase-Associated Lipocalin in Decompensated Liver Cirrhosis with Spontaneous Bacterial Peritonitis Patients. EKB Journal Management System, 91(1), 4511-4516. doi: 10.21608/ejhm.2023.296755
Rashed Mohamed Hassan; Ghada Abd Elghafar Salem; Bassem Mohamed ALsayed Refaat Mohamed; Amal Ahmed Zidan; Ahmed M. El-Gebaly. "Prognostic Value of Ascitic Neutrophil Gelatinase-Associated Lipocalin in Decompensated Liver Cirrhosis with Spontaneous Bacterial Peritonitis Patients". EKB Journal Management System, 91, 1, 2023, 4511-4516. doi: 10.21608/ejhm.2023.296755
Hassan, R., Salem, G., Mohamed, B., Zidan, A., El-Gebaly, A. (2023). 'Prognostic Value of Ascitic Neutrophil Gelatinase-Associated Lipocalin in Decompensated Liver Cirrhosis with Spontaneous Bacterial Peritonitis Patients', EKB Journal Management System, 91(1), pp. 4511-4516. doi: 10.21608/ejhm.2023.296755
Hassan, R., Salem, G., Mohamed, B., Zidan, A., El-Gebaly, A. Prognostic Value of Ascitic Neutrophil Gelatinase-Associated Lipocalin in Decompensated Liver Cirrhosis with Spontaneous Bacterial Peritonitis Patients. EKB Journal Management System, 2023; 91(1): 4511-4516. doi: 10.21608/ejhm.2023.296755

Prognostic Value of Ascitic Neutrophil Gelatinase-Associated Lipocalin in Decompensated Liver Cirrhosis with Spontaneous Bacterial Peritonitis Patients

The Egyptian Journal of Hospital Medicine
Article 115, Volume 91, Issue 1, April 2023, Page 4511-4516  XML PDF (618.76 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2023.296755
View on SCiNiTO View on SCiNiTO
Authors
Rashed Mohamed Hassan; Ghada Abd Elghafar Salem; Bassem Mohamed ALsayed Refaat Mohamed email ; Amal Ahmed Zidan; Ahmed M. El-Gebaly
Abstract
Background: In cirrhotic individuals, spontaneous bacterial peritonitis (SBP) is a relatively frequent complication. NGAL, or lipocalin linked with neutrophil gelatinase, is a trustworthy indicator of inflammation.
Objective: The aim of this work was to evaluate the prognostic value of ascitic neutrophil gelatinase associated lipocalin in decompensated liver cirrhosis with SBP patients.
Patients and Methods: The study comprised 72 patients with cirrhotic liver and ascites, they were categorized into two groups SBP group and non SBP group, each group had 36 patients. Each patient had a thorough history-taking process, physical examination, pelvic-abdominal ultrasonography, laboratory tests, and chemical and bacterial analysis of ascitic fluid samples and specific assay of NGAL levels using ELISA technique.
Results: We found thatthe optimum cutoff value of NGAL was ≥230.05 ng/ml with (AUC) 0.989, 89.5% positive predictive value, 94.4% specificity, 88.9%, and -94.4% negative predictive value 94.1% and overall accuracy 91.7%. The optimum cutoff of ascitic fluid NGAL in prediction of mortality is ≥401 ng/ml with (AUC) 1, 94.4% overall accuracy, 85.7% of positive predictive value, 100% of negative predictive value, 100% of sensitivity.
Conclusion: Ascitic fluid NGAL can be used not only for SBP diagnosis but also for prediction of SBP patients' short-term prognosis.
Keywords: 
Keywords
Neutrophil gelatinase associated lipocalin (NGAL); Ascites; Spontaneous bacterial peritonitis (SBP); Cirrhosis
Statistics
Article View: 104
PDF Download: 190