Inhalation of Sevoflurane Versus Intravenous Ketamine, Midazolam and Propofol For Sedation in Pediatrics Undergoing Upper Gastrointestinal Endoscopy | ||||
| Zagazig University Medical Journal | ||||
| Article 20, Volume 29, Issue 4, July and August 2023, Page 1135-1145 PDF (562.98 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2023.205551.2789 | ||||
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| Authors | ||||
Nahla Mohamed Amin  1; Zainab Sawan 2; salih Salim bahri3; Woud Mohyeldin Abdelfattah 4
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| 1Department of anesthesia zagazig University | ||||
| 2Anesthesia department, Faculty of Medicine, Zagazig University | ||||
| 3department of anesthesia | ||||
| 4departement of anesthesia zagazig university | ||||
| Abstract | ||||
| Background: Many anesthetics and sedative drugs can be used for sedation in upper gastrointestinal endoscopy (UGE) in pediatrics, however recovery profile and safety are priorities. Objectives: To compare the recovery profile from sedation and complications of sevoflurane inhalation with intravenous ketamine, midazolam and propofol combination for sedation in pediatrics scheduled for elective UGE. Patients and methods: This prospective randomized comparative clinical study included 74 pediatric patients aged one to four years old, ASA I or II who were scheduled for an elective UGE. They were randomly allocated into two groups; Group S (n=37): received inhalational 7% sevoflurane in oxygen via face mask for induction of sedation and 4% for maintenance via nasal cannula and Group KMP (n=37): received intravenous ketamine (1mg/kg), midazolam (0.05mg/kg) and propofol (1mg/kg) combination as induction doses and incremental doses of propofol alone (0.5 mg/kg) IV for maintenance of sedation as needed. The recovery time from sedation and complications were compared. Results: The duration of recovery was significantly shorter in S Group than in (KMP) group (11.17±1.95 minutes versus17.09±2.50, P<0.001). Regarding complications, there were no significant differences between the two groups, but the incidence of oxygen desaturation was higher in the group (KMP) (13.5%) than in group (S).(5.4 %), however it was statistically non-significant ( P 0.233) Conclusion: Sedation technique using inhalation of sevoflurane provides faster recovery from sedation and more safety than intravenous ketamine, midazolam, and propofol combination and can be utilized as a safe alternative technique for sedation in children undergoing elective UGE. | ||||
| Keywords | ||||
| children; inhalation intravenous endoscope sedation | ||||
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