Evaluation of bioactivity, antibacterial, and cytotoxicity of the glass ceramic based on akermanite glass containing Ag2O
El adawy, B., A. Salma, A., S. Zayed, H., Mabrouk, M., Hamzawy, E. (2023). Evaluation of bioactivity, antibacterial, and cytotoxicity of the glass ceramic based on akermanite glass containing Ag2O. EKB Journal Management System, 66(13), 939-949. doi: 10.21608/ejchem.2023.197674.7671
Basma Yousef El adawy; Aida A. Salma; Heba S. Zayed; Mostafa Mabrouk; Esmat M A Hamzawy. "Evaluation of bioactivity, antibacterial, and cytotoxicity of the glass ceramic based on akermanite glass containing Ag2O". EKB Journal Management System, 66, 13, 2023, 939-949. doi: 10.21608/ejchem.2023.197674.7671
El adawy, B., A. Salma, A., S. Zayed, H., Mabrouk, M., Hamzawy, E. (2023). 'Evaluation of bioactivity, antibacterial, and cytotoxicity of the glass ceramic based on akermanite glass containing Ag2O', EKB Journal Management System, 66(13), pp. 939-949. doi: 10.21608/ejchem.2023.197674.7671
El adawy, B., A. Salma, A., S. Zayed, H., Mabrouk, M., Hamzawy, E. Evaluation of bioactivity, antibacterial, and cytotoxicity of the glass ceramic based on akermanite glass containing Ag2O. EKB Journal Management System, 2023; 66(13): 939-949. doi: 10.21608/ejchem.2023.197674.7671

Evaluation of bioactivity, antibacterial, and cytotoxicity of the glass ceramic based on akermanite glass containing Ag2O

Egyptian Journal of Chemistry
Volume 66, Issue 13, December 2023, Page 939-949  XML PDF (2.71 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.197674.7671
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Authors
Basma Yousef El adawy email 1; Aida A. Salma1; Heba S. Zayed1; Mostafa Mabroukorcid 2; Esmat M A Hamzawyorcid 3
1Faculty of Science, Al-Azhar University (Girls) , Nassar City Cairo
2Ceramics Department, Inorganic chemistry industrial division, National Research Centre.
3Glass Research Dep
Abstract
Akermanite-based glass ceramics were prepared with /without Ag2O. Different techniques (DTA, XRD, SEM, and FTIR) are used for the characterization of the synthesized samples. For all prepared glass-ceramic samples, bioactivity, degradation, and ion release were tested in simulated body fluid (SBF). Also, the antibacterial effect was tested with Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Moreover, the cytotoxicity against the normal fibroblast (Wi-38) cell line was studied. DTA shows the addition of Ag2O lowered the glass transition temperatures to a little extent. the XRD results show that raising the sintering temperature from 900 ˚C to 1000 ˚C led to more crystallinity of Akermanite, cuspidine, and monticellite phases. The microstructure shows submicron crystals in a glassy matrix. After immersion in SBF, nano- and submicron particles of hydroxyapatite were detected in all samples. The integration of silver in the samples enhanced their ability to form hydroxyapatite and increased their antibacterial activity. Cytotoxicity test indicated that all samples up to concentration 125 um/ml had no toxic effect on cells and could be safely used as biocompatible materials.
Keywords
Akermanite based glass ceramic; Ag2O; bioactivity; antibacterial; cytotoxicity
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