The Early Predictive Role of Serum Zonulin Level for COVID-19 Severity in Patients Survival
Abbas, A., Mashhour, M., Ali, H., Seyadat, S., Ali, R., Al-Ghazali, M., Madlool, A., Salman, M., Brbber, A., AL- Rufaie, M. (2023). The Early Predictive Role of Serum Zonulin Level for COVID-19 Severity in Patients Survival. EKB Journal Management System, 15(1), 375-391. doi: 10.21608/eajbsc.2023.297202
Aiman Jawad Abbas; Muthana Saleh Mashhour; Hanaa Addai Ali; Sayed Omid Ranai Seyadat; Rawaa Adday Ali; Majid Jawad Al-Ghazali; Ammar Kareem Madlool; Mohammed Saeed Salman; Azhar Mohammed Brbber; Mohammed Majeed A AL- Rufaie. "The Early Predictive Role of Serum Zonulin Level for COVID-19 Severity in Patients Survival". EKB Journal Management System, 15, 1, 2023, 375-391. doi: 10.21608/eajbsc.2023.297202
Abbas, A., Mashhour, M., Ali, H., Seyadat, S., Ali, R., Al-Ghazali, M., Madlool, A., Salman, M., Brbber, A., AL- Rufaie, M. (2023). 'The Early Predictive Role of Serum Zonulin Level for COVID-19 Severity in Patients Survival', EKB Journal Management System, 15(1), pp. 375-391. doi: 10.21608/eajbsc.2023.297202
Abbas, A., Mashhour, M., Ali, H., Seyadat, S., Ali, R., Al-Ghazali, M., Madlool, A., Salman, M., Brbber, A., AL- Rufaie, M. The Early Predictive Role of Serum Zonulin Level for COVID-19 Severity in Patients Survival. EKB Journal Management System, 2023; 15(1): 375-391. doi: 10.21608/eajbsc.2023.297202

The Early Predictive Role of Serum Zonulin Level for COVID-19 Severity in Patients Survival

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
Volume 15, Issue 1, June 2023, Page 375-391  XML PDF (879.33 K)
Document Type: Original Article
DOI: 10.21608/eajbsc.2023.297202
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Authors
Aiman Jawad Abbas1; Muthana Saleh Mashhour1; Hanaa Addai Ali1; Sayed Omid Ranai Seyadat2; Rawaa Adday Ali3; Majid Jawad Al-Ghazali4; Ammar Kareem Madlool5; Mohammed Saeed Salman6; Azhar Mohammed Brbber7; Mohammed Majeed A AL- Rufaie1
1Department of Chemistry, Faculty of Science, University of Kufa, Najaf 54001, Iraq.
2Protein Research Center of Shahid Beheshti University, Iran.
3Microbiology Department, College of Veterinary Medicine, Al-Qasim Green University Babylon 51001, Iraq.
4Al-Hakim General Hospital / Najaf – Iraq.
5Medical Laboratory Techniques Department, Imam Ja'afar Al-Sadiq University, Al-Najaf 54001, Iraq.
6AL-Sadr Medical City/Najaf –Iraq.
7Ministry of Education, Muthanna Education Directorate/ Iraq.
Abstract
Background: Coronavirus disease 2019 (COVID-19) is a new infectious disease caused by the SARS-CoV-2 coronavirus, which first appeared in Wuhan and quickly spread around the world. The Middle-East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS) outbreaks in 2003 and more recently have demonstrated how lethal CoVs can be when they infect humans across the species barrier. The novel severe acute respiratory syndrome coronavirus 2 has threatened the world in many ways (SARS-CoV-2). Zonulin is a member of a protein family whose first member, pre-haptoglobin 2 (HP2), was discovered nearly ten years ago. (Rittirsch D 2013).Materials and Methods: A total of 120 Covid-19 patients' serum samples were collected and an apparently healthy group (n=60) with an age range (of 35-75) years, was admitted from AL- Amal Hospital. Zonulin levels were measured by enzyme-linked immunosorbent assay (ELISA) (kit. Metabolic parameters were measured by enzymatic spectrophotometer methods. The correlation coefficients between serum Zonulin levels and age, BMI, Elements and electrolytes were also evaluated.Results: Serum Zonulin, CRP, D-dimer and ferritin levels were significantly higher in Patients with COVID-19 (324.4±12.46) vs in control (79.69±11.77), (42.67±1.84) vs in control (3.36±0.25), (4188.21±198.73) vs in control (289.43±251) and (738±20.09) vs in control (130.66±9.2) (P <0.001). The correlation of Zonulin levels in COVID-19 patients was significantly positive with age, CRP, D-dimer and ferritin levels but negative with Iron, Ca and Na levels. The serum of Zonulin levels in moderate COVID-19 patients significantly high compared with the critical and severe patients group.Conclusions: Serum Zonulin levels increased in COVID-19 patients, especially in severe cases. Therefore, Zonulin levels demonstrate a prognostic value for predicting the severity of COVID-19. Continuous Zonulin results throughout the study period revealed that the severe group's values were higher than those of the non-severe group.
Keywords
COVID-19; Serum Zonulin; C-reactive protein; Ferritin and Electrolytes
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