Vitamin D supplementation in vitamin deficient women undergoing ICSI cycles: Does it affect the fertility outcome? A randomized controlled trial
Omran, E., Shohayeb, A., Gad-Allah, S., Gad, M., Sharaf, M., Abdallah, M. (2023). Vitamin D supplementation in vitamin deficient women undergoing ICSI cycles: Does it affect the fertility outcome? A randomized controlled trial. EKB Journal Management System, 27(2), 16-23. doi: 10.21608/egyfs.2023.297252
Eman F Omran; Amal Shohayeb; Sherine H Gad-Allah; Mona Gad; Marwa Fouad Sharaf; Mohamed S Abdallah. "Vitamin D supplementation in vitamin deficient women undergoing ICSI cycles: Does it affect the fertility outcome? A randomized controlled trial". EKB Journal Management System, 27, 2, 2023, 16-23. doi: 10.21608/egyfs.2023.297252
Omran, E., Shohayeb, A., Gad-Allah, S., Gad, M., Sharaf, M., Abdallah, M. (2023). 'Vitamin D supplementation in vitamin deficient women undergoing ICSI cycles: Does it affect the fertility outcome? A randomized controlled trial', EKB Journal Management System, 27(2), pp. 16-23. doi: 10.21608/egyfs.2023.297252
Omran, E., Shohayeb, A., Gad-Allah, S., Gad, M., Sharaf, M., Abdallah, M. Vitamin D supplementation in vitamin deficient women undergoing ICSI cycles: Does it affect the fertility outcome? A randomized controlled trial. EKB Journal Management System, 2023; 27(2): 16-23. doi: 10.21608/egyfs.2023.297252

Vitamin D supplementation in vitamin deficient women undergoing ICSI cycles: Does it affect the fertility outcome? A randomized controlled trial

The Egyptian Journal of Fertility of Sterility
Article 4, Volume 27, Issue 2 - Serial Number 11106352, March 2023, Page 16-23  XML PDF (2.91 MB)
Document Type: Original Article
DOI: 10.21608/egyfs.2023.297252
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Authors
Eman F Omran email 1; Amal Shohayeb2; Sherine H Gad-Allah2; Mona Gad2; Marwa Fouad Sharaf2; Mohamed S Abdallah3
1Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Saray St., Al-Manial 11956, Cairo, Egypt
2Department of obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt
3Department of Clinical and Chemical pathology, Faculty of Medicine, Cairo University, Cairo, Egypt
Abstract
Objective: to determine the effect of vitamin D (VD) supplementation on ICSI outcome in vitamin D deficient females.
Methods: A randomized controlled trial was done in IVF unit of Cairo University from July 2017 to Mach 2021. Level of VD was measured (females with level below 30 ng/ml were eligible). 400 VD deficient (or insufficient) females randomly allocated to 2 groups; VD supplementation (group 1) and non-supplemented group (group 2). Outcome data were analyzed for 187 participants in group 1 and for 186 in group 2. Regression analysis was done to calculate the Odds ratio (OR) for the primary outcome (clinical pregnancy rate, CPR) adjusting for confounders (age, BMI, type and cause of infertility). The study secondary outcome were the fertilization and the implantation rates.
Results: Group 1 had higher fertilization (86% vs 64%, difference of 18%; 95%CI; 14%, 21%, p<0.01) and implantation rates (27% vs 17%, difference 10%; 95%CI 4%, 16%, p<0.01). CPR was higher in group1 (83/187, 44% vs 63/186, 34%, difference of 10%, 95%CI; 1%, 20%; p=0.03). After adjustment, the Odds ratio for pregnancy in group 1 was 2.1 (95%CI: 2.1, 3.3, p=0.01), Conclusion: VD supplementation increases the clinical pregnancy, fertilization and implantation rates in ICSI cycles.

ClinicalTrial.gov Registration number: NCT03209856.
Keywords
Vitamin D; Infertility; IVF; ICSI
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