Efficacy of Trichloroacetic Acid in Patients with Alopecia Areata: A Clinico-Histopathological Study | ||||
| International Journal of Medical Arts | ||||
| Article 4, Volume 5, Issue 2, February 2023, Page 3033-3038 PDF (807.57 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2023.197060.1634 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Hossam Mamdouh Anter  ; Amr M. Zaky; Ahmed H. Nouh; Mohamed El-Khalawany
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| Department of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Alopecia areata is an autoimmune disorder caused by a breakdown in the follicular immune privilege system, resulting in non-scarring hair loss. Many therapeutic options have been tested with variable results. Aim of the work: To assess the efficacy of trichloroacetic acid [TCA] 35% in patients of alopecia areata. Patients and Methods: This prospective cross-sectional study included 40 patients recruited from department of dermatology and venereology, Al-Hussein hospital. Every patient was treated by 3 sessions of TCA 35% with one-month intervals. The assessment was done by clinical, trichoscopy, and histopathological examination. Results: The study included 40 patients, 22 males [55%] and18 females [45%]. The mean age of studied patients was 25.6 ± 8.6 years with a minimum age of 16 years and a maximum age of 50 years. The duration of the disease ranged between 2 months and 10 years with a mean duration of 2.7 ± 2.5 years. Thirty patients [75%] showed improvement at the end of TCA sessions. Conclusion: Based on our findings, topical application of TCA 35% is a safe and effective treatment option for patients with alopecia areata. Moreover, it can be used in wide areas of the scalp and cases of alopecia totalis. | ||||
| Keywords | ||||
| Alopecia; Hair loss; Alopecia areata; Trichloroacetic acid | ||||
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