Protective Effects of Curcumin and Selenium on Testicular Toxicity Induced by Lead Acetate in Adult Male Albino Rats [Structural and Biochemical Study] | ||||
International Journal of Medical Arts | ||||
Article 6, Volume 5, Issue 2, February 2023, Page 3045-3053 PDF (1.68 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ijma.2023.203141.1659 | ||||
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Authors | ||||
Alsayed A. Abdel Hady1; Ezz-Eldin E. Abd-Allah 2; Nahed M. M. Emam3; Alaa Eldein Sayed El-Sagheer4; Amr M. Younes5; Ahmed S. Abdel Monsef6; Amany M. Wahb7; Ahmed E. Moustafa8; Mokhtar A. Mokhtar Abo-Elfotoh9; E. M. Tayee10; Noha O. Shawky11 | ||||
1Department of Anatomy, Faculty of Medicine, Helwan University, Helwan, Egypt. | ||||
2Department of Histology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt | ||||
3Department of Zoology, Faculty of Science, Al Arish University, North Sinai, Egypt | ||||
4Department of Anatomy, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
5Department of Anatomy and Embryology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt | ||||
6Department of Physiology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt. | ||||
7Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Helwan University, Helwan, Egypt | ||||
8Department of Medical Biochemistry, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt. | ||||
9Department of Forensic Medicine and Clinical Toxicology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt | ||||
10Department of Clinical Pharmacology, Faculty of Medicine, Helwan University, Helwan, Egypt. | ||||
11Department of Medical Physiology, Faculty of Medicine, Helwan University, Helwan, Egypt | ||||
Abstract | ||||
Background: Several industrial products [such as paints, cosmetics, and petrol] contained metals like lead [Pb], which are harmful to people. The reproductive organs are the primary organs affected by heavy metal toxicity through the production of oxidative stress. Selenium and curcumin could help to counteract this toxicity. Aim of the work: We investigated the possible role of Selenium or curcumin in improving the testicular toxicity caused by the intake of Lead orally in albino rats. Materials and Methods: 40 adult male albino rats were selected and unsystematically separated into 4 groups [10 rats/each] included: Group 1: control group; Group 2: Pb-exposed group; Group 3: Pb plus Selenium and Group 4: Pb plus Curcumin. Blood samples were collected for examination of serum biochemical parameters, serum Testosterone, LH, FSH levels, Total Anti-oxidant Capacity [TAC], testicular tissue oxidative stress parameters and testicular histology were evaluated. Results: Oral administration of Pb to rats for 4 weeks disturbs the testicular structure and function with a significant increase in the oxidative stress enzymes, deposition of collagen fibers and anticaspase-3 in the testis. While, administration of either Selenium or Curcumin with Pb-exposure induced significant improvement of all the testicular changes. Conclusion: Chronic lead exposure causes deteriorating changes in the testicular structures and functions which could be improved by oral intake of either Selenium or Curcumin by their antioxidant, antifibrotic, and antiapoptotic properties. | ||||
Keywords | ||||
Lead; Testis; Oxidative stress; Selenium; Curcumin | ||||
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