A randomized double-blinded clinical trial to explore the clinical outcome of self-administered vaginal isonicotinic acid hydrazide (INH) administration 12 hours before hysterosalpingography in primarily infertile patients
shady, N., Taha, A., Ahmed, H., Sallam, H. (2023). A randomized double-blinded clinical trial to explore the clinical outcome of self-administered vaginal isonicotinic acid hydrazide (INH) administration 12 hours before hysterosalpingography in primarily infertile patients. EKB Journal Management System, 27(2), 54-64. doi: 10.21608/egyfs.2023.297300
nahla w shady; Ahmed A. Taha; Hala Maher Ahmed; Hany F. Sallam. "A randomized double-blinded clinical trial to explore the clinical outcome of self-administered vaginal isonicotinic acid hydrazide (INH) administration 12 hours before hysterosalpingography in primarily infertile patients". EKB Journal Management System, 27, 2, 2023, 54-64. doi: 10.21608/egyfs.2023.297300
shady, N., Taha, A., Ahmed, H., Sallam, H. (2023). 'A randomized double-blinded clinical trial to explore the clinical outcome of self-administered vaginal isonicotinic acid hydrazide (INH) administration 12 hours before hysterosalpingography in primarily infertile patients', EKB Journal Management System, 27(2), pp. 54-64. doi: 10.21608/egyfs.2023.297300
shady, N., Taha, A., Ahmed, H., Sallam, H. A randomized double-blinded clinical trial to explore the clinical outcome of self-administered vaginal isonicotinic acid hydrazide (INH) administration 12 hours before hysterosalpingography in primarily infertile patients. EKB Journal Management System, 2023; 27(2): 54-64. doi: 10.21608/egyfs.2023.297300

A randomized double-blinded clinical trial to explore the clinical outcome of self-administered vaginal isonicotinic acid hydrazide (INH) administration 12 hours before hysterosalpingography in primarily infertile patients

The Egyptian Journal of Fertility of Sterility
Article 9, Volume 27, Issue 2 - Serial Number 11106352, March 2023, Page 54-64  XML PDF (3.76 MB)
Document Type: Original Article
DOI: 10.21608/egyfs.2023.297300
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Authors
nahla w shady email orcid 1; Ahmed A. Taha2; Hala Maher Ahmed3; Hany F. Sallam4
1Professor at the Department of Obstetrics and Gynecology, Consultant at Aswan University Hospital, Aswan University, Aswan, Egypt
21- Obstetrics and Gynecology Department, Aswan Faculty of Medicine, Aswan University, Aswan Governorate, Egypt
3Department of Diagnostic Radiology, Aswan Faculty of Medicine, Aswan, Egypt
4Obstetrics and Gynecology Department, Aswan Faculty of Medicine, Aswan University, Aswan Governorate, Egypt
Abstract
Objective: The purpose of this study was to assess the clinical outcomes of using a combination of oral Ketoprofen and vaginal isonicotinic acid hydrazide (INH) for pain management during hysterosalpingography (HSG) vs using solely oral Ketoprofen.
Methods: The randomized controlled study was conducted between August 2020 and September 2021. Infertile women scheduled for HSG were randomized (1:1) to Ketoprofen with or without INH. All women received oral 150 mg Ketoprofen plus 900 mg vaginal INH or placebo tablets 12 hours before the procedure. The primary outcome was the participant's self-rated pain perception utilizing a 10-cm Visual Analogue Scale (VAS). During speculum insertion, cervical tenaculum application, dye injection, and 5 and 30 minutes following the procedure, the participants' self-rat- ed pain was assessed using a 10-cm VAS.
Results: A total of 200 women participated (100 in each group). Oral Ketoprofen combined with vaginal INH substantially lowers the major VAS pain ratings during dye injection (4.23 ± 0.89 vs. 6.18 ± 0.90), 5-minute post-procedure (3.05 ± 0.95 vs. 5.81 ± 0.91), and 30-minute post-procedure (2.14 ± 0.74 vs. 4.69 ± 0.80), with p 0.01 at all phases. After using a speculum or tenaculum, there were no significant differences in VAS values. In terms of side effects, there was no significant difference between the study groups.
Conclusion: Adjuvant vaginal INH to oral Ketoprofen 12 hours before HSG may be considerably more effective than Ketoprofen alone in reducing the caused pain score during and 30 minutes after the HSG procedure.
Keywords
Hysterosalpingography; INH, NSAIDs; infertile; pain
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