PREVALENCE OF METABOLIC DYSFUNCTION- ASSOCIATED FATTY LIVER DISEASE IN EGYPTIAN PATIENTS WITH HEPATOCELLULAR CARCINOMA | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Volume 53, Issue 1, April 2023, Page 93-100 PDF (793.28 K) | ||||
| DOI: 10.21608/jesp.2023.297350 | ||||
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| Authors | ||||
| HODA MOHAMMED FARID; EMAN MAHMOUD BARAKAT; MOHAMMED KAMAL SHAKER; DOAA ZAKARIA ZAKY; IMAN FAWZY MONTASSER; YASSER ARAFAT ABDELRAZIK | ||||
| Department of Tropical Medicine, Faculty of Medicine, Ain Shams University Hospitals, Cairo, Egypt | ||||
| Abstract | ||||
| Hepatocellular carcinoma is the third common cause of mortality worldwide with major changes of the prevalence of different etiologies. Nowadays we found more conflicting data about metabolic dysfunction -associated fatty liver disease (MAFLD) and its effect on a major spectrum of liver diseases as an increasing cause of hepatocellular carcinoma worldwide. The study was to assessed prevalence of MAFLD as a single causes of HCC among HCC patients presented to the Hepatoma specialized outpatient clinic and to evalute effect on tumor burden and survival as compared to HCV infection patients related HCC. Twenty nine patients with MAFLD related HCC were included in group A while 58 patients with HCV related HCC were enrolled as group B .In group (A) ; the mean age was 58.86 (+8.47) years, this group included 20 male patients (68.97%) and 9 female patients (31.03%). While in group (B); the mean age was 60/05(+ 6.83) years, with 45 males (77.59%) and 13 females (22.41%) without significant difference between both as to age (P=0.482) or sexes (P=0.383). In the MAFLD related HCC group there were 19 /29 patients (65.5%) had Diabetes mellitus, 15 patients (51.7%) had hypertension and 9 patients (31%) were on antidyslipidimic drugs. The mean Body mass index (BMI) was 29kg/m2 (±SD 2.81) Also, comparison between groups regarding tumor burden and characteristics of HCC, Child Pugh score, or Barcelona clinic liver cancer (BCLC ) showed no significant statistical difference between both groups except for lymph node metastases which was higher in patients with HCV related HCC. One year survival rate was higher in MAFLD group (72.4%) than of that in HCV related HCC group (58.6%) however, no significant statistical difference between both groups p=0.184 | ||||
| Keywords | ||||
| Metabolic (dysfunction) associated fatty liver disease; cirrhosis; Hepatocellular carcinoma | ||||
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